{"id":12810,"date":"2024-05-01T13:55:21","date_gmt":"2024-05-01T13:55:21","guid":{"rendered":"https:\/\/www.drknowhk.org\/?p=12810"},"modified":"2024-06-26T14:02:10","modified_gmt":"2024-06-26T14:02:10","slug":"a-body-brain-circuit-that-regulates-body-inflammatory-responses","status":"publish","type":"post","link":"http:\/\/www.drknowhk.org\/mo\/a-body-brain-circuit-that-regulates-body-inflammatory-responses\/","title":{"rendered":"A body\u2013brain circuit that regulates body inflammatory responses"},"content":{"rendered":"<p class=\"qtranxs-available-languages-message qtranxs-available-languages-message-mo\">\u5c0d\u4e0d\u8d77\uff0c\u6b64\u5185\u5bb9\u53ea\u9069\u7528\u65bc<a href=\"http:\/\/www.drknowhk.org\/en\/wp-json\/wp\/v2\/posts\/12810\" class=\"qtranxs-available-language-link qtranxs-available-language-link-en\" title=\"English\">English<\/a>\u3002<\/p><p>By Hao Jin et al.<\/p>\n<p>Source:Nature<\/p>\n<p>The body\u2013brain axis is emerging as a principal conductor of organismal physiology. It senses and controls organ function<sup><a id=\"ref-link-section-d12836532e510\" title=\"Guyenet, P. G. &amp; Bayliss, D. A. Neural control of breathing and CO2 homeostasis. Neuron 87, 946\u2013961 (2015).\" href=\"https:\/\/www.nature.com\/articles\/s41586-024-07469-y#ref-CR1\" data-track=\"click\" data-track-action=\"reference anchor\" data-track-label=\"link\" data-test=\"citation-ref\" aria-label=\"Reference 1\">1<\/a>,<a id=\"ref-link-section-d12836532e513\" title=\"Prescott, S. L. &amp; Liberles, S. D. Internal senses of the vagus nerve. Neuron 110, 579\u2013599 (2022).\" href=\"https:\/\/www.nature.com\/articles\/s41586-024-07469-y#ref-CR2\" data-track=\"click\" data-track-action=\"reference anchor\" data-track-label=\"link\" data-test=\"citation-ref\" aria-label=\"Reference 2\">2<\/a><\/sup>, metabolism<sup><a id=\"ref-link-section-d12836532e517\" title=\"Myers, M. G. Jr &amp; Olson, D. P. Central nervous system control of metabolism. Nature 491, 357\u2013363 (2012).\" href=\"https:\/\/www.nature.com\/articles\/s41586-024-07469-y#ref-CR3\" data-track=\"click\" data-track-action=\"reference anchor\" data-track-label=\"link\" data-test=\"citation-ref\" aria-label=\"Reference 3\">3<\/a><\/sup>\u00a0and nutritional state<sup><a id=\"ref-link-section-d12836532e521\" title=\"Augustine, V., Lee, S. &amp; Oka, Y. Neural control and modulation of thirst, sodium appetite, and hunger. Cell 180, 25\u201332 (2020).\" href=\"https:\/\/www.nature.com\/articles\/s41586-024-07469-y#ref-CR4\" data-track=\"click\" data-track-action=\"reference anchor\" data-track-label=\"link\" data-test=\"citation-ref\">4<\/a>,<a id=\"ref-link-section-d12836532e521_1\" title=\"Li, M. et al. Gut\u2013brain circuits for fat preference. Nature 610, 722\u2013730 (2022).\" href=\"https:\/\/www.nature.com\/articles\/s41586-024-07469-y#ref-CR5\" data-track=\"click\" data-track-action=\"reference anchor\" data-track-label=\"link\" data-test=\"citation-ref\">5<\/a>,<a id=\"ref-link-section-d12836532e524\" title=\"Tan, H. E. et al. The gut\u2013brain axis mediates sugar preference. Nature 580, 511\u2013516 (2020).\" href=\"https:\/\/www.nature.com\/articles\/s41586-024-07469-y#ref-CR6\" data-track=\"click\" data-track-action=\"reference anchor\" data-track-label=\"link\" data-test=\"citation-ref\" aria-label=\"Reference 6\">6<\/a><\/sup>. Here we show that a peripheral immune insult strongly activates the body\u2013brain axis to regulate immune responses. We demonstrate that pro-inflammatory and anti-inflammatory cytokines communicate with distinct populations of vagal neurons to inform the brain of an emerging inflammatory response. In turn, the brain tightly modulates the course of the peripheral immune response. Genetic silencing of this body\u2013brain circuit produced unregulated and out-of-control inflammatory responses.<\/p>\n<p>Read more<a href=\"https:\/\/www.nature.com\/articles\/s41586-024-07469-y\"> https:\/\/www.nature.com\/articles\/s41586-024-07469-y<\/a><\/p>","protected":false},"excerpt":{"rendered":"<p>\u5c0d\u4e0d\u8d77\uff0c\u6b64\u5185\u5bb9\u53ea\u9069\u7528\u65bcEnglish\u3002By Hao Jin et al. Source:Nature The body\u2013brain axis is emerging as a principal conductor of organismal physiology. It senses and controls organ function1,2, metabolism3\u00a0and nutritional state4,5,6. Here we show that a peripheral immune insult strongly activates the body\u2013brain axis to regulate immune responses. We demonstrate that pro-inflammatory and anti-inflammatory cytokines communicate with distinct populations [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":12811,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[49],"tags":[],"class_list":["post-12810","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-brain-cancer-metabolic-syndrome-og"],"_links":{"self":[{"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/posts\/12810","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/comments?post=12810"}],"version-history":[{"count":1,"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/posts\/12810\/revisions"}],"predecessor-version":[{"id":12812,"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/posts\/12810\/revisions\/12812"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/media\/12811"}],"wp:attachment":[{"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/media?parent=12810"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/categories?post=12810"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/tags?post=12810"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}