{"id":12887,"date":"2024-04-26T14:18:56","date_gmt":"2024-04-26T14:18:56","guid":{"rendered":"https:\/\/www.drknowhk.org\/?p=12887"},"modified":"2024-06-27T14:21:22","modified_gmt":"2024-06-27T14:21:22","slug":"cell-%e7%bb%bc%e8%bf%b0%e5%a4%a9%e7%84%b6%e5%85%8d%e7%96%ab%e4%ba%94%e5%8d%81%e5%b9%b4","status":"publish","type":"post","link":"http:\/\/www.drknowhk.org\/mo\/cell-%e7%bb%bc%e8%bf%b0%e5%a4%a9%e7%84%b6%e5%85%8d%e7%96%ab%e4%ba%94%e5%8d%81%e5%b9%b4\/","title":{"rendered":"Cell: \u7efc\u8ff0\u5929\u7136\u514d\u75ab\u4e94\u5341\u5e74"},"content":{"rendered":"<p>\u51fa\u8655\uff1a\u00a0<span class=\"rich_media_meta rich_media_meta_text\">immunity\u901f\u8bfb<\/span><\/p>\n<section>\u5728\u8fc7\u53bb\u7684\u4e94\u5341\u5e74\u91cc\uff0c\u6211\u4eec\u5bf9\u5929\u7136\u514d\u75ab\u7cfb\u7edf\u7684\u7406\u89e3\u53d1\u751f\u4e86\u663e\u8457\u7684\u8f6c\u53d8\u3002\u5929\u7136\u514d\u75ab\u66fe\u7ecf\u88ab\u89c6\u4e3a\u4e00\u79cd\u539f\u59cb\u7684\u975e\u7279\u5f02\u6027\u9632\u5fa1\u673a\u5236\uff0c\u73b0\u5728\u5df2\u6210\u4e3a\u4e00\u4e2a\u4e2d\u5fc3\u821e\u53f0\uff0c\u663e\u793a\u51fa\u9ad8\u5ea6\u590d\u6742\u7684\u7ec6\u80de\u548c\u5206\u5b50\u8fc7\u7a0b\u7f51\u7edc\u3002<\/section>\n<section>\u6628\u5929\uff0c\u90fd\u67cf\u6797\u5723\u4e09\u4e00\u5927\u5b66Luke A.J. O\u2019Neill\u3001\u52a0\u5dde\u5927\u5b66\u5723\u514b\u9c81\u65af\u5206\u6821Susan Carpenter\u5171\u540c\u901a\u8baf\u5728\u300aCell\u300b\u53d1\u8868\u7efc\u8ff0\u201c<strong>From periphery to center stage: 50 years of advancements in innate immunity<\/strong>\u201d\uff0c\u6982\u8ff0\u4e86\u5929\u7136\u514d\u75ab\u7814\u7a76\u9886\u57df\u8fd1\u4e94\u5341\u5e74\u7684\u8fdb\u5c55\u3002<\/section>\n<section>\u8be5\u9886\u57df\u7684\u4e00\u4e2a\u5173\u952e\u7a81\u7834\u662f\u53d1\u73b0\u4e86\u6a21\u5f0f\u8bc6\u522b\u53d7\u4f53\uff08PRR\uff09\uff0c\u8fd9\u662f\u4e00\u4e2a\u53ef\u4ee5\u68c0\u6d4b\u75c5\u539f\u4f53\u6216\u5371\u9669\u4fe1\u53f7\u4e2d\u53d1\u73b0\u7684\u4fdd\u5b88\u5206\u5b50\u6a21\u5f0f\u5e76\u5bf9\u5176\u505a\u51fa\u53cd\u5e94\u7684\u53d7\u4f53\u5bb6\u65cf\u3002\u7814\u7a76\u6700\u5145\u5206\u7684PRR\u662fToll\u6837\u53d7\u4f53\uff08TLR\uff09\uff0c\u5b83\u8bc6\u522b\u5e7f\u6cdb\u7684\u5fae\u751f\u7269\u6210\u5206\uff0c\u5982\u6765\u81ea\u9769\u5170\u6c0f\u9634\u6027\u83cc\u7684\u8102\u591a\u7cd6\uff08\u7531TLR4\u611f\u77e5\uff09\u548c\u6765\u81ea\u7ec6\u83cc\u548c\u75c5\u6bd2\u7684\u672a\u7532\u57fa\u5316CpG DNA\uff08\u7531TLR9\u611f\u77e5\uff09\u3002<\/section>\n<section>\u53e6\u4e00\u4e2a\u5173\u952e\u53d1\u73b0\u662f\u708e\u75c7\u5c0f\u4f53\u3002\u708e\u75c7\u5c0f\u4f53\u662f\u4e00\u79cd\u5728\u4fc3\u708e\u7ec6\u80de\u56e0\u5b50IL-1\u03b2\u548cIL-18\u7684\u6fc0\u6d3b\u4ee5\u53ca\u7126\u4ea1\u4e2d\u8d77\u7740\u81f3\u5173\u91cd\u8981\u7684\u4f5c\u7528\u7684\u591a\u86cb\u767d\u590d\u5408\u7269\u3002\u7279\u522b\u662fNLRP3\u708e\u75c7\u5c0f\u4f53\uff0c\u7531\u4e8e\u5176\u5bf9\u5404\u79cd\u523a\u6fc0\uff08\u5305\u62ec\u79bb\u5b50\u901a\u91cf\u3001\u4ee3\u8c22\u53d8\u5316\u548c\u6838\u9178\uff09\u7684\u53cd\u5e94\u80fd\u529b\u800c\u5f15\u8d77\u4e86\u4eba\u4eec\u7684\u6781\u5927\u5173\u6ce8\uff0c\u4f7f\u5176\u6210\u4e3a\u5404\u79cd\u708e\u75c7\u548c\u81ea\u8eab\u514d\u75ab\u75be\u75c5\u7684\u6f5c\u5728\u6cbb\u7597\u9776\u70b9\u3002<\/section>\n<section><\/section>\n<section>\u95b1\u8b80\u5168\u6587\uff1a<a href=\"https:\/\/mp.weixin.qq.com\/s\/L0pP8WL8eKFaMz3UfiUiAA\">https:\/\/mp.weixin.qq.com\/s\/L0pP8WL8eKFaMz3UfiUiAA<\/a><\/section>\n<p><\/p>","protected":false},"excerpt":{"rendered":"<p>\u51fa\u8655\uff1a\u00a0immunity\u901f\u8bfb \u5728\u8fc7\u53bb\u7684\u4e94\u5341\u5e74\u91cc\uff0c\u6211\u4eec\u5bf9\u5929\u7136\u514d\u75ab\u7cfb\u7edf\u7684\u7406\u89e3\u53d1\u751f\u4e86\u663e\u8457\u7684\u8f6c\u53d8\u3002\u5929\u7136\u514d\u75ab\u66fe\u7ecf\u88ab\u89c6\u4e3a\u4e00\u79cd\u539f\u59cb\u7684\u975e\u7279\u5f02\u6027\u9632\u5fa1\u673a\u5236\uff0c\u73b0\u5728\u5df2\u6210\u4e3a\u4e00\u4e2a\u4e2d\u5fc3\u821e\u53f0\uff0c\u663e\u793a\u51fa\u9ad8\u5ea6\u590d\u6742\u7684\u7ec6\u80de\u548c\u5206\u5b50\u8fc7\u7a0b\u7f51\u7edc\u3002 \u6628\u5929\uff0c\u90fd\u67cf\u6797\u5723\u4e09\u4e00\u5927\u5b66Luke A.J. O\u2019Neill\u3001\u52a0\u5dde\u5927\u5b66\u5723\u514b\u9c81\u65af\u5206\u6821Susan Carpenter\u5171\u540c\u901a\u8baf\u5728\u300aCell\u300b\u53d1\u8868\u7efc\u8ff0\u201cFrom periphery to center stage: 50 years of advancements in innate immunity\u201d\uff0c\u6982\u8ff0\u4e86\u5929\u7136\u514d\u75ab\u7814\u7a76\u9886\u57df\u8fd1\u4e94\u5341\u5e74\u7684\u8fdb\u5c55\u3002 \u8be5\u9886\u57df\u7684\u4e00\u4e2a\u5173\u952e\u7a81\u7834\u662f\u53d1\u73b0\u4e86\u6a21\u5f0f\u8bc6\u522b\u53d7\u4f53\uff08PRR\uff09\uff0c\u8fd9\u662f\u4e00\u4e2a\u53ef\u4ee5\u68c0\u6d4b\u75c5\u539f\u4f53\u6216\u5371\u9669\u4fe1\u53f7\u4e2d\u53d1\u73b0\u7684\u4fdd\u5b88\u5206\u5b50\u6a21\u5f0f\u5e76\u5bf9\u5176\u505a\u51fa\u53cd\u5e94\u7684\u53d7\u4f53\u5bb6\u65cf\u3002\u7814\u7a76\u6700\u5145\u5206\u7684PRR\u662fToll\u6837\u53d7\u4f53\uff08TLR\uff09\uff0c\u5b83\u8bc6\u522b\u5e7f\u6cdb\u7684\u5fae\u751f\u7269\u6210\u5206\uff0c\u5982\u6765\u81ea\u9769\u5170\u6c0f\u9634\u6027\u83cc\u7684\u8102\u591a\u7cd6\uff08\u7531TLR4\u611f\u77e5\uff09\u548c\u6765\u81ea\u7ec6\u83cc\u548c\u75c5\u6bd2\u7684\u672a\u7532\u57fa\u5316CpG DNA\uff08\u7531TLR9\u611f\u77e5\uff09\u3002 \u53e6\u4e00\u4e2a\u5173\u952e\u53d1\u73b0\u662f\u708e\u75c7\u5c0f\u4f53\u3002\u708e\u75c7\u5c0f\u4f53\u662f\u4e00\u79cd\u5728\u4fc3\u708e\u7ec6\u80de\u56e0\u5b50IL-1\u03b2\u548cIL-18\u7684\u6fc0\u6d3b\u4ee5\u53ca\u7126\u4ea1\u4e2d\u8d77\u7740\u81f3\u5173\u91cd\u8981\u7684\u4f5c\u7528\u7684\u591a\u86cb\u767d\u590d\u5408\u7269\u3002\u7279\u522b\u662fNLRP3\u708e\u75c7\u5c0f\u4f53\uff0c\u7531\u4e8e\u5176\u5bf9\u5404\u79cd\u523a\u6fc0\uff08\u5305\u62ec\u79bb\u5b50\u901a\u91cf\u3001\u4ee3\u8c22\u53d8\u5316\u548c\u6838\u9178\uff09\u7684\u53cd\u5e94\u80fd\u529b\u800c\u5f15\u8d77\u4e86\u4eba\u4eec\u7684\u6781\u5927\u5173\u6ce8\uff0c\u4f7f\u5176\u6210\u4e3a\u5404\u79cd\u708e\u75c7\u548c\u81ea\u8eab\u514d\u75ab\u75be\u75c5\u7684\u6f5c\u5728\u6cbb\u7597\u9776\u70b9\u3002 \u95b1\u8b80\u5168\u6587\uff1ahttps:\/\/mp.weixin.qq.com\/s\/L0pP8WL8eKFaMz3UfiUiAA<\/p>\n","protected":false},"author":1,"featured_media":12817,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[33],"tags":[],"class_list":["post-12887","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-western-medicine"],"_links":{"self":[{"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/posts\/12887","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/comments?post=12887"}],"version-history":[{"count":1,"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/posts\/12887\/revisions"}],"predecessor-version":[{"id":12888,"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/posts\/12887\/revisions\/12888"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/media\/12817"}],"wp:attachment":[{"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/media?parent=12887"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/categories?post=12887"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/tags?post=12887"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}