{"id":13220,"date":"2024-06-14T14:17:46","date_gmt":"2024-06-14T14:17:46","guid":{"rendered":"https:\/\/www.drknowhk.org\/?p=13220"},"modified":"2024-07-12T14:20:22","modified_gmt":"2024-07-12T14:20:22","slug":"mendelian-randomization-supports-causality-between-covid-19-and-glaucoma","status":"publish","type":"post","link":"http:\/\/www.drknowhk.org\/mo\/mendelian-randomization-supports-causality-between-covid-19-and-glaucoma\/","title":{"rendered":"Mendelian randomization supports causality between COVID-19 and glaucoma"},"content":{"rendered":"

\u5c0d\u4e0d\u8d77\uff0c\u6b64\u5185\u5bb9\u53ea\u9069\u7528\u65bcEnglish<\/a>\u3002<\/p>

By Maolin Chen et al.<\/p>\n

Source Medicine<\/p>\n

Abstract<\/h2>\n
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To determine whether there is a causal relationship between Corona Virus Disease 2019 (COVID-19) and glaucoma, a 2-sample Mendelian Randomization (MR) design was applied with the main analysis method of inverse-variance-weighted. The reliability of the results was checked using the heterogeneity test, pleiotropy test, and leave-one-out method. Four sets of instrumental variables (IVs) were used to investigate the causality between COVID-19 and glaucoma risk according to data from the IEU Genome Wide Association Study (GWAS). The results showed that 2 sets of COVID-19(RELEASE) were significantly associated with the risk of glaucoma [ID: ebi-a-GCST011071, OR (95% CI)\u2005=\u20051.227 (1.076\u20131.400),\u00a0P<\/em>\u2005=\u2005.002259; ID: ebi-a-GCST011073: OR (95% CI)\u2005=\u20051.164 (1.022\u20131.327),\u00a0P<\/em>\u2005=\u2005.022450; 2 sets of COVID-19 hospitalizations were significantly associated with the risk of glaucoma (ID: ebi-a-GCST011081, OR (95% CI)\u2005=\u20051.156 (1.033\u20131.292),\u00a0P<\/em>\u2005=\u2005.011342; ID: ebi-a-GCST011082: OR (95% CI)\u2005=\u20051.097 (1.007\u20131.196),\u00a0P<\/em>\u2005=\u2005.034908)]. The sensitivity of the results was acceptable (P<\/em>\u2005>\u2005.05) for the 3 test methods. In conclusion, this MR analysis provides preliminary evidence of a potential causal relationship between COVID-19 and glaucoma.<\/p>\n

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\u5c0d\u4e0d\u8d77\uff0c\u6b64\u5185\u5bb9\u53ea\u9069\u7528\u65bcEnglish\u3002By Maolin Chen et al. Source Medicine Abstract To determine whether there is a causal relationship between Corona Virus Disease 2019 (COVID-19) and glaucoma, a 2-sample Mendelian Randomization (MR) design was applied with the main analysis method of inverse-variance-weighted. The reliability of the results was checked using the heterogeneity test, pleiotropy test, and leave-one-out method. […]<\/p>\n","protected":false},"author":1,"featured_media":13215,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[56,21],"tags":[],"class_list":["post-13220","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-evidence-based-research-in-western-medicine-clinical-practice","category-scientific-reports"],"_links":{"self":[{"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/posts\/13220","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/comments?post=13220"}],"version-history":[{"count":1,"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/posts\/13220\/revisions"}],"predecessor-version":[{"id":13222,"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/posts\/13220\/revisions\/13222"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/media\/13215"}],"wp:attachment":[{"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/media?parent=13220"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/categories?post=13220"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/tags?post=13220"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}