{"id":13955,"date":"2024-04-26T14:40:47","date_gmt":"2024-04-26T14:40:47","guid":{"rendered":"https:\/\/www.drknowhk.org\/?p=13955"},"modified":"2024-08-15T14:43:51","modified_gmt":"2024-08-15T14:43:51","slug":"increased-galanin-galanin-receptor-1-signaling-inflammation-and-insulin-resistance-are-associated-with-affective-symptoms-and-chronic-fatigue-syndrome-due-to-long-covid","status":"publish","type":"post","link":"http:\/\/www.drknowhk.org\/mo\/increased-galanin-galanin-receptor-1-signaling-inflammation-and-insulin-resistance-are-associated-with-affective-symptoms-and-chronic-fatigue-syndrome-due-to-long-covid\/","title":{"rendered":"Increased galanin-galanin receptor 1 signaling, inflammation, and insulin resistance are associated with affective symptoms and chronic fatigue syndrome due to Long COVID"},"content":{"rendered":"<p class=\"qtranxs-available-languages-message qtranxs-available-languages-message-mo\">\u5c0d\u4e0d\u8d77\uff0c\u6b64\u5185\u5bb9\u53ea\u9069\u7528\u65bc<a href=\"http:\/\/www.drknowhk.org\/en\/wp-json\/wp\/v2\/posts\/13955\" class=\"qtranxs-available-language-link qtranxs-available-language-link-en\" title=\"English\">English<\/a>\u3002<\/p><p>By Wasim Talib Mahdi Al Masoodi et al.<\/p>\n<p>Source medRxiv<\/p>\n<h2 class=\"\">Abstract<\/h2>\n<div id=\"sec-1\" class=\"subsection\">\n<p id=\"p-3\"><strong>Background<\/strong>\u00a0Long COVID (LC) patients frequently suffer from neuropsychiatric symptoms, including depression, anxiety, and chronic fatigue syndrome (CFS), relabeled as the physio-affective phenome of LC. Activated immune-inflammatory pathways and insulin resistance key play a role in these physio-affective symptoms due to LC.<\/p>\n<\/div>\n<div id=\"sec-2\" class=\"subsection\">\n<p id=\"p-4\"><strong>Aims<\/strong>\u00a0To examine the associations between the Hamilton Depression (HAMD), Hamilton Anxiety (HAMA) and Fibro-Fatigue (FF) Rating Scale scores and serum C-reactive protein (CRP), prostaglandin E2 (PGE2), galanin-galanin receptor 1 (GAL-GALR1) signaling, insulin resistance, insulin-like growth factor (IGF-1), plasminogen activator inhibitor-1 (PAI1), and damage biomarkers such as S100B and neuron-specific enolase (NSE) in 90 subjects 3-6 months after acute SARS-CoV-2 infection.<\/p>\n<\/div>\n<div id=\"sec-3\" class=\"subsection\">Read more<a href=\"https:\/\/www.drknowhk.org\/wp-content\/uploads\/2024\/08\/2024.04.25.24306334v1.full_.pdf\"> click here<\/a><\/div>\n<p>&nbsp;<\/p>","protected":false},"excerpt":{"rendered":"<p>\u5c0d\u4e0d\u8d77\uff0c\u6b64\u5185\u5bb9\u53ea\u9069\u7528\u65bcEnglish\u3002By Wasim Talib Mahdi Al Masoodi et al. Source medRxiv Abstract Background\u00a0Long COVID (LC) patients frequently suffer from neuropsychiatric symptoms, including depression, anxiety, and chronic fatigue syndrome (CFS), relabeled as the physio-affective phenome of LC. Activated immune-inflammatory pathways and insulin resistance key play a role in these physio-affective symptoms due to LC. Aims\u00a0To examine the [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":13785,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[51,21],"tags":[],"class_list":["post-13955","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-clinical-manifestations-epidemiology","category-scientific-reports"],"_links":{"self":[{"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/posts\/13955","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/comments?post=13955"}],"version-history":[{"count":1,"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/posts\/13955\/revisions"}],"predecessor-version":[{"id":13957,"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/posts\/13955\/revisions\/13957"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/media\/13785"}],"wp:attachment":[{"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/media?parent=13955"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/categories?post=13955"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/tags?post=13955"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}