{"id":14150,"date":"2024-07-12T08:48:50","date_gmt":"2024-07-12T08:48:50","guid":{"rendered":"https:\/\/www.drknowhk.org\/?p=14150"},"modified":"2024-08-26T08:54:49","modified_gmt":"2024-08-26T08:54:49","slug":"initiator-cell-death-event-induced-by-sars-cov-2-in-the-human-airway-epithelium","status":"publish","type":"post","link":"http:\/\/www.drknowhk.org\/mo\/initiator-cell-death-event-induced-by-sars-cov-2-in-the-human-airway-epithelium\/","title":{"rendered":"Initiator cell death event induced by SARS-CoV- 2 in the human airway epithelium"},"content":{"rendered":"<p class=\"qtranxs-available-languages-message qtranxs-available-languages-message-mo\">\u5c0d\u4e0d\u8d77\uff0c\u6b64\u5185\u5bb9\u53ea\u9069\u7528\u65bc<a href=\"http:\/\/www.drknowhk.org\/en\/wp-json\/wp\/v2\/posts\/14150\" class=\"qtranxs-available-language-link qtranxs-available-language-link-en\" title=\"English\">English<\/a>\u3002<\/p><p>By Kaixin Liang et al.<\/p>\n<p>Source Science Immunology<\/p>\n<section id=\"editor-abstract\" role=\"doc-abstract\">\n<h2>Editor\u2019s summary<\/h2>\n<div role=\"paragraph\">SARS-CoV-2 infection triggers multiple cell death pathways that contribute to disease severity. Here, Liang <i>et al<\/i>. characterized cell death mechanisms in angiotensin-converting enzyme 2 (ACE2)\u2013expressing cells and primary human airway epithelial (HAE) cell cultures during SARS-CoV-2 infection and in autopsied lungs from patients with COVID-19. Necroptosis was the primary form of cell death and was induced by viral Z-RNA binding to Z-DNA binding protein-1 (ZBP-1). Infected and bystander cells underwent apoptosis, but limiting dilution analysis showed that apoptosis was a bystander effect. The Delta variant induced much greater Z-RNA\/ZBP-1 interactions and necroptosis compared with Omicron, thus suggesting a mechanism associated with greater disease severity (see related Focus by Wong and Perlman). \u2014Christiana N. Fogg<\/div>\n<div role=\"paragraph\"><\/div>\n<div role=\"paragraph\">Read more <a href=\"https:\/\/www.drknowhk.org\/wp-content\/uploads\/2024\/08\/sciimmunol.adn0178.pdf\">click here<\/a><\/div>\n<div role=\"paragraph\"><\/div>\n<\/section>\n<p><\/p>","protected":false},"excerpt":{"rendered":"<p>\u5c0d\u4e0d\u8d77\uff0c\u6b64\u5185\u5bb9\u53ea\u9069\u7528\u65bcEnglish\u3002By Kaixin Liang et al. Source Science Immunology Editor\u2019s summary SARS-CoV-2 infection triggers multiple cell death pathways that contribute to disease severity. Here, Liang et al. characterized cell death mechanisms in angiotensin-converting enzyme 2 (ACE2)\u2013expressing cells and primary human airway epithelial (HAE) cell cultures during SARS-CoV-2 infection and in autopsied lungs from patients with COVID-19. [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":14152,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[21,52],"tags":[],"class_list":["post-14150","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-scientific-reports","category-virology-pathophysiology"],"_links":{"self":[{"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/posts\/14150","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/comments?post=14150"}],"version-history":[{"count":1,"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/posts\/14150\/revisions"}],"predecessor-version":[{"id":14153,"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/posts\/14150\/revisions\/14153"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/media\/14152"}],"wp:attachment":[{"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/media?parent=14150"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/categories?post=14150"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/tags?post=14150"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}