{"id":14188,"date":"2024-07-06T09:49:34","date_gmt":"2024-07-06T09:49:34","guid":{"rendered":"https:\/\/www.drknowhk.org\/?p=14188"},"modified":"2024-08-26T09:53:30","modified_gmt":"2024-08-26T09:53:30","slug":"sars-cov-2-amyloid-is-covid-19-exacerbated-dementia-an-amyloid-disorder-in-the-making","status":"publish","type":"post","link":"http:\/\/www.drknowhk.org\/mo\/sars-cov-2-amyloid-is-covid-19-exacerbated-dementia-an-amyloid-disorder-in-the-making\/","title":{"rendered":"SARS-CoV-2 amyloid, is COVID-19-exacerbated dementia an amyloid disorder in the making?"},"content":{"rendered":"<p class=\"qtranxs-available-languages-message qtranxs-available-languages-message-mo\">\u5c0d\u4e0d\u8d77\uff0c\u6b64\u5185\u5bb9\u53ea\u9069\u7528\u65bc<a href=\"http:\/\/www.drknowhk.org\/en\/wp-json\/wp\/v2\/posts\/14188\" class=\"qtranxs-available-language-link qtranxs-available-language-link-en\" title=\"English\">English<\/a>\u3002<\/p><p>By <span class=\"author-wrapper\">Nathaniel G. N. Milton<\/span><\/p>\n<p>Source Frontiers<\/p>\n<h2>1. Introduction<\/h2>\n<p class=\"mb15\">The COVID-19 pandemic, caused by infection with the SARS-CoV-2 virus, is associated with patients suffering neurological symptoms including cognitive impairment (Hosp et al., 2021; Spudich and Nath, 2022; Taquet et al., 2022) plus an increase in the levels of dementia and Alzheimer&#8217;s disease (AD) progression (Chen et al., 2022; Gordon et al., 2022; Golzari-Sorkheh et al., 2023; Olivera et al., 2023). The SARS-CoV-2 genome and proteome have been sequenced and components of the virus targeted for diagnosis and therapy (Hu et al., 2021; Kukar et al., 2021; Mishra et al., 2021; Yadav et al., 2021). The SARS-CoV-2 spike protein forms a trimer (Wrapp et al., 2020) that binds the angiotensin-converting enzyme 2 (ACE2) receptor on host cell surfaces to gain entry into the cells (Benton et al., 2020). Mutations of the receptor binding domain of the SARS-CoV-2 spike protein are found in a number of the variants of concern that show altered binding to the ACE2 receptor (Kim et al., 2023) and this also influences neurological symptoms (Taquet et al., 2022). The SARS-CoV-2 virus has been found in post-mortem brains (Crunfli et al., 2022; Stein et al., 2022), but some studies have failed to detect it (Khan et al., 2022). The mechanism of SARS-CoV-2 entry into the brain may involve either transmission via the nasal cavity (Butowt and von Bartheld, 2022) and\/or an impaired blood-brain barrier (Yang et al., 2022). The key question is if the SARS-CoV-2 virus itself causes dementia and\/or if SARS-CoV-2 infection exacerbates existing dementia (Paterson et al., 2020; Danics et al., 2021; Ecarnot et al., 2023). Dementia has many forms (Garcia-Ptacek et al., 2014) and some forms are associated with infections (Shinjyo et al., 2021).<\/p>\n<p>Read more<a href=\"https:\/\/www.drknowhk.org\/wp-content\/uploads\/2024\/08\/frdem-02-1233340.pdf\"> click here<\/a><\/p>","protected":false},"excerpt":{"rendered":"<p>\u5c0d\u4e0d\u8d77\uff0c\u6b64\u5185\u5bb9\u53ea\u9069\u7528\u65bcEnglish\u3002By Nathaniel G. N. Milton Source Frontiers 1. Introduction The COVID-19 pandemic, caused by infection with the SARS-CoV-2 virus, is associated with patients suffering neurological symptoms including cognitive impairment (Hosp et al., 2021; Spudich and Nath, 2022; Taquet et al., 2022) plus an increase in the levels of dementia and Alzheimer&#8217;s disease (AD) progression (Chen [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":14190,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[51,21,52],"tags":[],"class_list":["post-14188","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-clinical-manifestations-epidemiology","category-scientific-reports","category-virology-pathophysiology"],"_links":{"self":[{"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/posts\/14188","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/comments?post=14188"}],"version-history":[{"count":1,"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/posts\/14188\/revisions"}],"predecessor-version":[{"id":14191,"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/posts\/14188\/revisions\/14191"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/media\/14190"}],"wp:attachment":[{"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/media?parent=14188"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/categories?post=14188"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/tags?post=14188"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}