{"id":14203,"date":"2024-01-06T08:16:55","date_gmt":"2024-01-06T08:16:55","guid":{"rendered":"https:\/\/www.drknowhk.org\/?p=14203"},"modified":"2024-08-27T08:22:05","modified_gmt":"2024-08-27T08:22:05","slug":"interaction-of-toll-like-receptors-and-ace-2-with-different-variants-of-sars-cov-2-a-computational-analysis","status":"publish","type":"post","link":"http:\/\/www.drknowhk.org\/mo\/interaction-of-toll-like-receptors-and-ace-2-with-different-variants-of-sars-cov-2-a-computational-analysis\/","title":{"rendered":"Interaction of toll-like receptors and ACE-2 with different variants of SARS-CoV-2: A computational analysis"},"content":{"rendered":"<p class=\"qtranxs-available-languages-message qtranxs-available-languages-message-mo\">\u5c0d\u4e0d\u8d77\uff0c\u6b64\u5185\u5bb9\u53ea\u9069\u7528\u65bc<a href=\"http:\/\/www.drknowhk.org\/en\/wp-json\/wp\/v2\/posts\/14203\" class=\"qtranxs-available-language-link qtranxs-available-language-link-en\" title=\"English\">English<\/a>\u3002<\/p><p>By Azadeh Zahmatkesh et al.<\/p>\n<p>Source BioImpacts<\/p>\n<h2 class=\"title\">Abstract<\/h2>\n<div id=\"eng-abstract\" class=\"abstract-content selected\">\n<p><strong class=\"sub-title\"> Introduction: <\/strong> Computational studies were performed to investigate the unknown status of endosomal and cell surface receptors in SARS-CoV-2 infection. The interactions between Toll-like receptors (TLRs)- 4\/7\/8\/9 or ACE2 receptor and different SARS-CoV-2 variants were investigated.<\/p>\n<p><strong class=\"sub-title\"> Methods: <\/strong> The RNA motifs for TLR7, TLR8 and a CpG motif for TLR9 were analyzed in different variants. Molecular docking and molecular dynamics (MD) simulations were performed to investigate receptor-ligand interactions.<\/p>\n<p>Read more<a href=\"https:\/\/www.drknowhk.org\/wp-content\/uploads\/2024\/08\/bi-14-30150.pdf\"> click here<\/a><\/p>\n<\/div>\n<p><\/p>","protected":false},"excerpt":{"rendered":"<p>\u5c0d\u4e0d\u8d77\uff0c\u6b64\u5185\u5bb9\u53ea\u9069\u7528\u65bcEnglish\u3002By Azadeh Zahmatkesh et al. Source BioImpacts Abstract Introduction: Computational studies were performed to investigate the unknown status of endosomal and cell surface receptors in SARS-CoV-2 infection. The interactions between Toll-like receptors (TLRs)- 4\/7\/8\/9 or ACE2 receptor and different SARS-CoV-2 variants were investigated. Methods: The RNA motifs for TLR7, TLR8 and a CpG motif for [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":14205,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[21,52],"tags":[],"class_list":["post-14203","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-scientific-reports","category-virology-pathophysiology"],"_links":{"self":[{"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/posts\/14203","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/comments?post=14203"}],"version-history":[{"count":1,"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/posts\/14203\/revisions"}],"predecessor-version":[{"id":14206,"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/posts\/14203\/revisions\/14206"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/media\/14205"}],"wp:attachment":[{"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/media?parent=14203"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/categories?post=14203"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/tags?post=14203"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}