{"id":14291,"date":"2024-07-29T09:24:35","date_gmt":"2024-07-29T09:24:35","guid":{"rendered":"https:\/\/www.drknowhk.org\/?p=14291"},"modified":"2024-08-29T09:28:31","modified_gmt":"2024-08-29T09:28:31","slug":"the-longitudinal-characterization-of-immune-responses-in-covid-19-patients-reveals-novel-prognostic-signatures-for-disease-severity-patients-survival-and-long-covid","status":"publish","type":"post","link":"http:\/\/www.drknowhk.org\/mo\/the-longitudinal-characterization-of-immune-responses-in-covid-19-patients-reveals-novel-prognostic-signatures-for-disease-severity-patients-survival-and-long-covid\/","title":{"rendered":"The longitudinal characterization of immune responses in COVID-19 patients reveals novel prognostic signatures for disease severity, patients\u2019 survival and long COVID"},"content":{"rendered":"<p class=\"qtranxs-available-languages-message qtranxs-available-languages-message-mo\">\u5c0d\u4e0d\u8d77\uff0c\u6b64\u5185\u5bb9\u53ea\u9069\u7528\u65bc<a href=\"http:\/\/www.drknowhk.org\/en\/wp-json\/wp\/v2\/posts\/14291\" class=\"qtranxs-available-language-link qtranxs-available-language-link-en\" title=\"English\">English<\/a>\u3002<\/p><p>By <span id=\"nameLine\" class=\"h1\" data-test-id=\"nameline\" data-bind=\"text: fullName\">Maddalena Noviello<\/span> et al.<\/p>\n<p>Source Frontiers<\/p>\n<p><b>Introduction:<\/b> SARS-CoV-2 pandemic still poses a significant burden on global health and economy, especially for symptoms persisting beyond the acute disease. COVID-19 manifests with various degrees of severity and the identification of early biomarkers capable of stratifying patient based on risk of progression could allow tailored treatments.<\/p>\n<p><b>Methods:<\/b> We longitudinally analyzed 67 patients, classified according to a WHO ordinal scale as having Mild, Moderate, or Severe COVID-19. Peripheral blood samples were prospectively collected at hospital admission and during a 6-month follow-up after discharge. Several subsets and markers of the innate and adaptive immunity were monitored as putative factors associated with COVID-19 symptoms.<\/p>\n<p><b>Results:<\/b> More than 50 immunological parameters were associated with disease severity. A decision tree including the main clinical, laboratory, and biological variables at admission identified low NK-cell precursors and CD14<sup>+<\/sup>CD91<sup>+<\/sup> monocytes, and high CD8<sup>+<\/sup> Effector Memory T cell frequencies as the most robust immunological correlates of COVID-19 severity and reduced survival. Moreover, low regulatory B-cell frequency at one month was associated with the susceptibility to develop long COVID at six months, likely due to their immunomodulatory ability.<\/p>\n<p><b>Discussion:<\/b> These results highlight the profound perturbation of the immune response during COVID-19. The evaluation of specific innate and adaptive immune-cell subsets allows to distinguish between different acute and persistent COVID-19 symptoms.<\/p>\n<p>Read more<a href=\"https:\/\/www.drknowhk.org\/wp-content\/uploads\/2024\/08\/fimmu-15-1381091.pdf\"> click here<\/a><\/p>","protected":false},"excerpt":{"rendered":"<p>\u5c0d\u4e0d\u8d77\uff0c\u6b64\u5185\u5bb9\u53ea\u9069\u7528\u65bcEnglish\u3002By Maddalena Noviello et al. Source Frontiers Introduction: SARS-CoV-2 pandemic still poses a significant burden on global health and economy, especially for symptoms persisting beyond the acute disease. COVID-19 manifests with various degrees of severity and the identification of early biomarkers capable of stratifying patient based on risk of progression could allow tailored treatments. Methods: [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":14294,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[51,90,21],"tags":[],"class_list":["post-14291","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-clinical-manifestations-epidemiology","category-long-covid19","category-scientific-reports"],"_links":{"self":[{"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/posts\/14291","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/comments?post=14291"}],"version-history":[{"count":1,"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/posts\/14291\/revisions"}],"predecessor-version":[{"id":14295,"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/posts\/14291\/revisions\/14295"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/media\/14294"}],"wp:attachment":[{"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/media?parent=14291"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/categories?post=14291"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/tags?post=14291"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}