{"id":14318,"date":"2024-08-28T14:40:14","date_gmt":"2024-08-28T14:40:14","guid":{"rendered":"https:\/\/www.drknowhk.org\/?p=14318"},"modified":"2024-09-01T14:45:37","modified_gmt":"2024-09-01T14:45:37","slug":"fibrin-drives-thromboinflammation-and-neuropathology-in-covid-19","status":"publish","type":"post","link":"http:\/\/www.drknowhk.org\/mo\/fibrin-drives-thromboinflammation-and-neuropathology-in-covid-19\/","title":{"rendered":"Fibrin drives thromboinflammation and neuropathology in COVID-19"},"content":{"rendered":"<p class=\"qtranxs-available-languages-message qtranxs-available-languages-message-mo\">\u5c0d\u4e0d\u8d77\uff0c\u6b64\u5185\u5bb9\u53ea\u9069\u7528\u65bc<a href=\"http:\/\/www.drknowhk.org\/en\/wp-json\/wp\/v2\/posts\/14318\" class=\"qtranxs-available-language-link qtranxs-available-language-link-en\" title=\"English\">English<\/a>\u3002<\/p><p>By Jae Kyu Ryu et al.<\/p>\n<p>Source Nature<\/p>\n<h2 id=\"Abs1\" class=\"c-article-section__title js-section-title js-c-reading-companion-sections-item\">Abstract<\/h2>\n<div id=\"Abs1-content\" class=\"c-article-section__content\">\n<p>Life-threatening thrombotic events and neurological symptoms are prevalent in COVID-19 and are\u00a0persistent in patients with long COVID experiencing post-acute sequelae of SARS-CoV-2 infection<sup>1,2,3,4<\/sup>. Despite the clinical evidence<sup>1,5,6,7<\/sup>, the underlying mechanisms of coagulopathy in COVID-19 and its consequences in inflammation and neuropathology remain poorly understood and treatment options are insufficient. Fibrinogen, the central structural component of blood clots, is abundantly deposited in the lungs and brains of patients with COVID-19, correlates with disease severity and is a predictive biomarker for post-COVID-19 cognitive deficits<sup>1,5,8,9,10<\/sup>.<\/p>\n<p>Read more <a href=\"https:\/\/www.drknowhk.org\/wp-content\/uploads\/2024\/09\/s41586-024-07873-41.pdf\">click here<\/a><\/p>\n<\/div>\n<p>&nbsp;<\/p>","protected":false},"excerpt":{"rendered":"<p>\u5c0d\u4e0d\u8d77\uff0c\u6b64\u5185\u5bb9\u53ea\u9069\u7528\u65bcEnglish\u3002By Jae Kyu Ryu et al. Source Nature Abstract Life-threatening thrombotic events and neurological symptoms are prevalent in COVID-19 and are\u00a0persistent in patients with long COVID experiencing post-acute sequelae of SARS-CoV-2 infection1,2,3,4. Despite the clinical evidence1,5,6,7, the underlying mechanisms of coagulopathy in COVID-19 and its consequences in inflammation and neuropathology remain poorly understood and treatment [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":14320,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[21,52],"tags":[],"class_list":["post-14318","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-scientific-reports","category-virology-pathophysiology"],"_links":{"self":[{"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/posts\/14318","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/comments?post=14318"}],"version-history":[{"count":1,"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/posts\/14318\/revisions"}],"predecessor-version":[{"id":14321,"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/posts\/14318\/revisions\/14321"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/media\/14320"}],"wp:attachment":[{"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/media?parent=14318"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/categories?post=14318"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/tags?post=14318"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}