{"id":14548,"date":"2024-09-17T13:58:12","date_gmt":"2024-09-17T13:58:12","guid":{"rendered":"https:\/\/www.drknowhk.org\/?p=14548"},"modified":"2024-09-18T14:01:49","modified_gmt":"2024-09-18T14:01:49","slug":"sars-cov-2-specific-cd8-t-cells-from-people-with-long-covid-establish-and-maintain-effector-phenotype-and-key-tcr-signatures-over-2-years","status":"publish","type":"post","link":"http:\/\/www.drknowhk.org\/mo\/sars-cov-2-specific-cd8-t-cells-from-people-with-long-covid-establish-and-maintain-effector-phenotype-and-key-tcr-signatures-over-2-years\/","title":{"rendered":"SARS-CoV-2-specific CD8+ T cells from people with long COVID establish and maintain effector phenotype and key TCR signatures over 2 years"},"content":{"rendered":"<p class=\"qtranxs-available-languages-message qtranxs-available-languages-message-mo\">\u5c0d\u4e0d\u8d77\uff0c\u6b64\u5185\u5bb9\u53ea\u9069\u7528\u65bc<a href=\"http:\/\/www.drknowhk.org\/en\/wp-json\/wp\/v2\/posts\/14548\" class=\"qtranxs-available-language-link qtranxs-available-language-link-en\" title=\"English\">English<\/a>\u3002<\/p><p>By Louise C. Rowntree et al.<\/p>\n<p>Source PNAS<\/p>\n<h2>Significance<\/h2>\n<div role=\"paragraph\">Long COVID occurs in small but important minority of patients following COVID-19, reducing quality of life and contributing to healthcare burden. Although research into underlying mechanisms is evolving, immunity is understudied. As the recall of T cell memory promotes more rapid recovery and ameliorates disease outcomes, establishment of robust memory T cells is important for protection against subsequent infections, even when the virus mutates. We defined how SARS-CoV-2-specific T cell and B cell responses are established and maintained following infection and vaccination for 2 y in people with long COVID. We found robust and prototypical SARS-CoV-2-specific T cells with effector phenotype and key T cell receptor signatures in people with long COVID following SARS-CoV-2 infection and subsequent COVID-19 vaccination.<\/div>\n<div role=\"paragraph\"><\/div>\n<div role=\"paragraph\">Read more <a href=\"https:\/\/www.drknowhk.org\/wp-content\/uploads\/2024\/09\/rowntree-et-al-2024-sars-cov-2-specific-cd8-t-cells-from-people-with-long-covid-establish-and-maintain-effector.pdf\">click here<\/a><\/div>\n<div class=\"page\" title=\"Page 1\">\n<div class=\"section\">\n<div class=\"layoutArea\">\n<div class=\"column\">\n<p>&nbsp;<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<p><\/p>","protected":false},"excerpt":{"rendered":"<p>\u5c0d\u4e0d\u8d77\uff0c\u6b64\u5185\u5bb9\u53ea\u9069\u7528\u65bcEnglish\u3002By Louise C. Rowntree et al. Source PNAS Significance Long COVID occurs in small but important minority of patients following COVID-19, reducing quality of life and contributing to healthcare burden. Although research into underlying mechanisms is evolving, immunity is understudied. As the recall of T cell memory promotes more rapid recovery and ameliorates disease outcomes, [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":14550,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[90,21,52],"tags":[],"class_list":["post-14548","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-long-covid19","category-scientific-reports","category-virology-pathophysiology"],"_links":{"self":[{"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/posts\/14548","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/comments?post=14548"}],"version-history":[{"count":1,"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/posts\/14548\/revisions"}],"predecessor-version":[{"id":14551,"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/posts\/14548\/revisions\/14551"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/media\/14550"}],"wp:attachment":[{"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/media?parent=14548"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/categories?post=14548"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/tags?post=14548"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}