{"id":14613,"date":"2024-02-01T13:58:40","date_gmt":"2024-02-01T13:58:40","guid":{"rendered":"https:\/\/www.drknowhk.org\/?p=14613"},"modified":"2024-09-23T14:03:33","modified_gmt":"2024-09-23T14:03:33","slug":"sars-cov-2-infection-causes-dopaminergic-neuron-senescence","status":"publish","type":"post","link":"http:\/\/www.drknowhk.org\/mo\/sars-cov-2-infection-causes-dopaminergic-neuron-senescence\/","title":{"rendered":"SARS-CoV-2 infection causes dopaminergic neuron senescence"},"content":{"rendered":"<p class=\"qtranxs-available-languages-message qtranxs-available-languages-message-mo\">\u5c0d\u4e0d\u8d77\uff0c\u6b64\u5185\u5bb9\u53ea\u9069\u7528\u65bc<a href=\"http:\/\/www.drknowhk.org\/en\/wp-json\/wp\/v2\/posts\/14613\" class=\"qtranxs-available-language-link qtranxs-available-language-link-en\" title=\"English\">English<\/a>\u3002<\/p><p>By Liuliu\u00a0Yang et al.<\/p>\n<p>Source Cell<\/p>\n<h2>Summary<\/h2>\n<div id=\"abspara0010\" role=\"paragraph\">COVID-19 patients commonly present with signs of central nervous system and\/or peripheral nervous system dysfunction. Here, we show that midbrain dopamine (DA) neurons derived from human pluripotent stem cells (hPSCs) are selectively susceptible and permissive to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. SARS-CoV-2 infection of DA neurons triggers an inflammatory and cellular senescence response. High-throughput screening in hPSC-derived DA neurons identified several FDA-approved drugs that can rescue the cellular senescence phenotype by preventing SARS-CoV-2 infection. We also identified the inflammatory and cellular senescence signature and low levels of SARS-CoV-2 transcripts in human substantia nigra tissue of COVID-19 patients. Furthermore, we observed reduced numbers of neuromelanin+ and tyrosine-hydroxylase (TH)+ DA neurons and fibers in a cohort of severe COVID-19 patients. Our findings demonstrate that hPSC-derived DA neurons are susceptible to SARS-CoV-2, identify candidate neuroprotective drugs for COVID-19 patients, and suggest the need for careful, long-term monitoring of neurological problems in COVID-19 patients.<\/div>\n<div role=\"paragraph\"><\/div>\n<div role=\"paragraph\">Read more <a href=\"https:\/\/www.cell.com\/cell-stem-cell\/fulltext\/S1934-5909(23)00442-3\">https:\/\/www.cell.com\/cell-stem-cell\/fulltext\/S1934-5909(23)00442-3<\/a><\/div>\n<p><\/p>","protected":false},"excerpt":{"rendered":"<p>\u5c0d\u4e0d\u8d77\uff0c\u6b64\u5185\u5bb9\u53ea\u9069\u7528\u65bcEnglish\u3002By Liuliu\u00a0Yang et al. Source Cell Summary COVID-19 patients commonly present with signs of central nervous system and\/or peripheral nervous system dysfunction. Here, we show that midbrain dopamine (DA) neurons derived from human pluripotent stem cells (hPSCs) are selectively susceptible and permissive to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. SARS-CoV-2 infection of DA [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":14614,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[21,52],"tags":[],"class_list":["post-14613","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-scientific-reports","category-virology-pathophysiology"],"_links":{"self":[{"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/posts\/14613","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/comments?post=14613"}],"version-history":[{"count":1,"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/posts\/14613\/revisions"}],"predecessor-version":[{"id":14615,"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/posts\/14613\/revisions\/14615"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/media\/14614"}],"wp:attachment":[{"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/media?parent=14613"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/categories?post=14613"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/tags?post=14613"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}