{"id":14625,"date":"2024-09-21T14:20:05","date_gmt":"2024-09-21T14:20:05","guid":{"rendered":"https:\/\/www.drknowhk.org\/?p=14625"},"modified":"2024-09-23T14:25:33","modified_gmt":"2024-09-23T14:25:33","slug":"changes-in-memory-and-cognition-during-the-sars-cov-2-human-challenge-study","status":"publish","type":"post","link":"http:\/\/www.drknowhk.org\/mo\/changes-in-memory-and-cognition-during-the-sars-cov-2-human-challenge-study\/","title":{"rendered":"Changes in memory and cognition during the SARS-CoV-2 human challenge study"},"content":{"rendered":"<p class=\"qtranxs-available-languages-message qtranxs-available-languages-message-mo\">\u5c0d\u4e0d\u8d77\uff0c\u6b64\u5185\u5bb9\u53ea\u9069\u7528\u65bc<a href=\"http:\/\/www.drknowhk.org\/en\/wp-json\/wp\/v2\/posts\/14625\" class=\"qtranxs-available-language-link qtranxs-available-language-link-en\" title=\"English\">English<\/a>\u3002<\/p><p>By William Trender et al.<\/p>\n<p>Source Lancet<\/p>\n<section id=\"abssec0010\">\n<h3>Background<\/h3>\n<div id=\"abspara0010\" role=\"paragraph\">Patient-reported outcomes and cross-sectional evidence show an association between COVID-19 and persistent cognitive problems. The causal basis, longevity and domain specificity of this association is unclear due to population variability in baseline cognitive abilities, vulnerabilities, virus variants, vaccination status and treatment.<\/div>\n<\/section>\n<section id=\"abssec0015\">\n<h3>Methods<\/h3>\n<div id=\"abspara0015\" role=\"paragraph\">Thirty-four young, healthy, seronegative volunteers were inoculated with Wildtype SARS-CoV-2 under prospectively controlled conditions. Volunteers completed daily physiological measurements and computerised cognitive tasks during quarantine and follow-up at 30, 90, 180, 270, and 360 days. Linear modelling examined differences between \u2018infected\u2019 and \u2018inoculated but uninfected\u2019 individuals. The main cognitive endpoint was the baseline corrected global cognitive composite score across the battery of tasks administered to the volunteers. Exploratory cognitive endpoints included baseline corrected scores from individual tasks. The study was registered on\u00a0ClinicalTrials.gov\u00a0with the identifier\u00a0NCT04865237\u00a0and took place between March 2021 and July\u00a02022.<\/div>\n<\/section>\n<div role=\"paragraph\"><\/div>\n<div role=\"paragraph\">Read more<a href=\"https:\/\/www.drknowhk.org\/wp-content\/uploads\/2024\/09\/PIIS2589537024004218.pdf\"> click here<\/a><\/div>\n<p><\/p>","protected":false},"excerpt":{"rendered":"<p>\u5c0d\u4e0d\u8d77\uff0c\u6b64\u5185\u5bb9\u53ea\u9069\u7528\u65bcEnglish\u3002By William Trender et al. Source Lancet Background Patient-reported outcomes and cross-sectional evidence show an association between COVID-19 and persistent cognitive problems. The causal basis, longevity and domain specificity of this association is unclear due to population variability in baseline cognitive abilities, vulnerabilities, virus variants, vaccination status and treatment. Methods Thirty-four young, healthy, seronegative volunteers [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":14627,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[49,128,51,21],"tags":[],"class_list":["post-14625","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-brain-cancer-metabolic-syndrome-og","category-brain","category-clinical-manifestations-epidemiology","category-scientific-reports"],"_links":{"self":[{"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/posts\/14625","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/comments?post=14625"}],"version-history":[{"count":1,"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/posts\/14625\/revisions"}],"predecessor-version":[{"id":14628,"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/posts\/14625\/revisions\/14628"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/media\/14627"}],"wp:attachment":[{"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/media?parent=14625"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/categories?post=14625"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/tags?post=14625"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}