{"id":14657,"date":"2024-09-27T15:12:30","date_gmt":"2024-09-27T15:12:30","guid":{"rendered":"https:\/\/www.drknowhk.org\/?p=14657"},"modified":"2024-09-29T15:14:59","modified_gmt":"2024-09-29T15:14:59","slug":"rna%e2%80%90seq-analysis-of-human-heart-tissue-reveals-sars%e2%80%90cov%e2%80%902-infection-and-inappropriate-activation-of-the-tnf%e2%80%90nf%e2%80%90%ce%bab-pathway-in-cardiomyocytes","status":"publish","type":"post","link":"http:\/\/www.drknowhk.org\/mo\/rna%e2%80%90seq-analysis-of-human-heart-tissue-reveals-sars%e2%80%90cov%e2%80%902-infection-and-inappropriate-activation-of-the-tnf%e2%80%90nf%e2%80%90%ce%bab-pathway-in-cardiomyocytes\/","title":{"rendered":"RNA\u2010Seq analysis of human heart tissue reveals SARS\u2010CoV\u20102 infection and inappropriate activation of the TNF\u2010NF\u2010\u03baB pathway in cardiomyocytes"},"content":{"rendered":"<p class=\"qtranxs-available-languages-message qtranxs-available-languages-message-mo\">\u5c0d\u4e0d\u8d77\uff0c\u6b64\u5185\u5bb9\u53ea\u9069\u7528\u65bc<a href=\"http:\/\/www.drknowhk.org\/en\/wp-json\/wp\/v2\/posts\/14657\" class=\"qtranxs-available-language-link qtranxs-available-language-link-en\" title=\"English\">English<\/a>\u3002<\/p><p>By Kirtan Dave et al.<\/p>\n<p>Source Nature<\/p>\n<h2 id=\"Abs1\" class=\"c-article-section__title js-section-title js-c-reading-companion-sections-item\">Abstract<\/h2>\n<div id=\"Abs1-content\" class=\"c-article-section__content\">\n<p>The negative impact of SARS-CoV-2 virus infection on cardiovascular disease (CVD) patients is well established. This research article explores the cellular pathways involved in underlying heart diseases after infection. The systemic inflammatory response to SARS-CoV-2 infection likely exacerbates this increased cardiovascular risk; however, whether the virus directly infects cardiomyocytes remains unknown due to limited multi-omics data. While public transcriptome data exists for COVID-19 infection in different cell types (including cardiomyocytes), infection times vary between studies. We used available RNA-seq data from human heart tissue to delineate SARS-CoV-2 infection and heart failure aetiology specific gene expression signatures. A total of fifty-four samples from four studies were analysed. Our aim was to investigate specific transcriptome changes occurring in cardiac tissue with SARS-CoV-2 infection compared to non-infected controls. Our data establish that SARS-CoV-2 infects cardiomyocytes by the TNF-NF-\u03baB pathway, potentially triggering acute cardiovascular complications and increasing the long-term cardiovascular risk in COVID-19 patients.<\/p>\n<\/div>\n<p>&nbsp;<\/p>\n<p>Read more <a href=\"https:\/\/www.drknowhk.org\/wp-content\/uploads\/2024\/09\/s41598-024-69635-6.pdf\">click here<\/a><\/p>","protected":false},"excerpt":{"rendered":"<p>\u5c0d\u4e0d\u8d77\uff0c\u6b64\u5185\u5bb9\u53ea\u9069\u7528\u65bcEnglish\u3002By Kirtan Dave et al. Source Nature Abstract The negative impact of SARS-CoV-2 virus infection on cardiovascular disease (CVD) patients is well established. This research article explores the cellular pathways involved in underlying heart diseases after infection. The systemic inflammatory response to SARS-CoV-2 infection likely exacerbates this increased cardiovascular risk; however, whether the virus directly [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":14659,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[21,52],"tags":[],"class_list":["post-14657","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-scientific-reports","category-virology-pathophysiology"],"_links":{"self":[{"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/posts\/14657","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/comments?post=14657"}],"version-history":[{"count":1,"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/posts\/14657\/revisions"}],"predecessor-version":[{"id":14660,"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/posts\/14657\/revisions\/14660"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/media\/14659"}],"wp:attachment":[{"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/media?parent=14657"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/categories?post=14657"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/tags?post=14657"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}