{"id":14708,"date":"2024-10-10T05:37:54","date_gmt":"2024-10-10T05:37:54","guid":{"rendered":"https:\/\/www.drknowhk.org\/?p=14708"},"modified":"2024-10-10T07:42:22","modified_gmt":"2024-10-10T07:42:22","slug":"elevated-serum-mtdna-in-covid%e2%80%9119-patients-is-linked-to-sars%e2%80%91cov%e2%80%912-envelope-protein-targeting-mitochondrial-vdac1-inducing-apoptosis-and-mtdna-release","status":"publish","type":"post","link":"http:\/\/www.drknowhk.org\/mo\/elevated-serum-mtdna-in-covid%e2%80%9119-patients-is-linked-to-sars%e2%80%91cov%e2%80%912-envelope-protein-targeting-mitochondrial-vdac1-inducing-apoptosis-and-mtdna-release\/","title":{"rendered":"Elevated serum mtDNA in COVID\u201119 patients is linked to SARS\u2011CoV\u20112 envelope protein targeting mitochondrial VDAC1, inducing apoptosis and mtDNA release"},"content":{"rendered":"

\u5c0d\u4e0d\u8d77\uff0c\u6b64\u5185\u5bb9\u53ea\u9069\u7528\u65bcEnglish<\/a>\u3002<\/p>

By Anna Shteinfer\u2011Kuzmine et al.<\/p>\n

Source Springer Link<\/p>\n

\n

Abstract<\/p>\n

Mitochondria dysfunction is implicated in cell death, inflammation, and autoimmunity. During viral infections, some viruses employ different strategies to disrupt mitochondria-dependent apoptosis, while others, including SARS-CoV-2, induce host cell apoptosis to facilitate replication and immune system modulation. Given mitochondrial DNAs (mtDNA) role as a pro-inflammatory damage-associated molecular pattern in inflammatory diseases, we examined its levels in the serum of COVID-19 patients and found it to be high relative to levels in healthy donors. Furthermore, comparison of serum protein profiles between healthy individuals and SARS-CoV-2-infected patients revealed unique bands in the COVID-19 patients. Using mass spectroscopy, we identified over 15 proteins, whose levels in the serum of COVID-19 patients were 4- to 780-fold higher. As mtDNA release from the mitochondria is mediated by the oligomeric form of the mitochondrial-gatekeeper\u2014the voltage-dependent anion-selective channel 1 (VDAC1)\u2014we investigated whether SARS-CoV-2 protein alters VDAC1 expression. Among the three selected SARS-CoV-2 proteins, small envelope (E), nucleocapsid (N), and accessory 3b proteins, the E-protein induced VDAC1 overexpression, VDAC1 oligomerization, cell death, and mtDNA release.<\/p>\n<\/div>\n

 <\/p>\n

Researchers suggest that COVID-19 pathology is associated with the induction of VDAC1 overexpression and oligomerization, leading to cell death and the release of mitochondrial vfmtDNA, which is associated with the cytokine storm that directly influences SARS-CoV-2 severity and the COVID-19 illness.<\/p>\n

E PROTEIN hence induced MITOCHONDRIAL DYSFUNCTION and apoptosis, leading to HIGH LEVELS of MITOCHONDRIA FRAGMENTS in the BLOOD \ud83d\ude28 – key pathways contributing to COVID-19 severity.<\/p>\n

\u96fb\u58d3\u4f9d\u8cf4\u6027\u9670\u96e2\u5b50\u9078\u64c7\u6027\u901a\u90531\uff08VDAC1\uff09\u662f\u4e00\u7a2e\u03b2\u6876\u86cb\u767d\uff0c\u5728\u4eba\u985e\u4e2d\u662f\u75315\u865f\u67d3\u8272\u9ad4\u4e0a\u7684VDAC1\u57fa\u56e0\u6240\u88fd\u9020[4][5]\u3002\u6b64\u86cb\u767d\u8cea\u6703\u5728\u7dda\u7c92\u9ad4\u5916\u819c\uff08OMM\uff09\u548c\u7d30\u80de\u819c\u4e2d\u5f62\u6210\u96e2\u5b50\u901a\u9053\uff1a\u5728OMM\u4e0a\uff0cATP\u901a\u904e\u8a72\u96e2\u5b50\u901a\u9053\u800c\u80fd\u81ea\u7dda\u7c92\u9ad4\u64f4\u6563\u81f3\u7d30\u80de\u8cea\uff1b\u5728\u7d30\u80de\u819c\u4e2d\uff0cVDAC1\u5247\u53c3\u8207\u9ad4\u7a4d\u7684\u8abf\u7bc0\u3002<\/p>\n

 <\/p>\n

Read more click here<\/a><\/p>","protected":false},"excerpt":{"rendered":"

\u5c0d\u4e0d\u8d77\uff0c\u6b64\u5185\u5bb9\u53ea\u9069\u7528\u65bcEnglish\u3002By Anna Shteinfer\u2011Kuzmine et al. Source Springer Link Abstract Mitochondria dysfunction is implicated in cell death, inflammation, and autoimmunity. During viral infections, some viruses employ different strategies to disrupt mitochondria-dependent apoptosis, while others, including SARS-CoV-2, induce host cell apoptosis to facilitate replication and immune system modulation. Given mitochondrial DNAs (mtDNA) role as a pro-inflammatory damage-associated […]<\/p>\n","protected":false},"author":1,"featured_media":14710,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[21,52],"tags":[],"class_list":["post-14708","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-scientific-reports","category-virology-pathophysiology"],"_links":{"self":[{"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/posts\/14708","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/comments?post=14708"}],"version-history":[{"count":1,"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/posts\/14708\/revisions"}],"predecessor-version":[{"id":14711,"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/posts\/14708\/revisions\/14711"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/media\/14710"}],"wp:attachment":[{"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/media?parent=14708"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/categories?post=14708"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/tags?post=14708"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}