{"id":14839,"date":"2024-10-14T08:49:58","date_gmt":"2024-10-14T08:49:58","guid":{"rendered":"https:\/\/www.drknowhk.org\/?p=14839"},"modified":"2024-10-17T08:54:22","modified_gmt":"2024-10-17T08:54:22","slug":"pulmonary-sars-cov-2-infection-leads-to-para-infectious-immune-activation-in-the-brain","status":"publish","type":"post","link":"http:\/\/www.drknowhk.org\/mo\/pulmonary-sars-cov-2-infection-leads-to-para-infectious-immune-activation-in-the-brain\/","title":{"rendered":"Pulmonary SARS-CoV-2 infection leads to para-infectious immune activation in the brain"},"content":{"rendered":"<p class=\"qtranxs-available-languages-message qtranxs-available-languages-message-mo\">\u5c0d\u4e0d\u8d77\uff0c\u6b64\u5185\u5bb9\u53ea\u9069\u7528\u65bc<a href=\"http:\/\/www.drknowhk.org\/en\/wp-json\/wp\/v2\/posts\/14839\" class=\"qtranxs-available-language-link qtranxs-available-language-link-en\" title=\"English\">English<\/a>\u3002<\/p><p>By <span class=\"author-wrapper\">Cordelia Dunai et al.<\/span><\/p>\n<p>Source Frontiers<\/p>\n<p>\u5fc3\u81df\u611f\u67d3\uff0c\u9059\u611f\u8166\u708e<\/p>\n<p>Latest findings suggest that a primarily pulmonary inflammatory process is rapidly associated with parainfectious immune activation in the brain and the signature of an NK cell and\/or T cell response which indicates a cascade of inflammation.<\/p>\n<p>Studies of brain organoids have reported that Iba1+ microglia engulf post-synaptic material contributing to synapse elimination.<\/p>\n<p>From previous studies, the virus was present at low amounts in the brain and was found predominantly in the vasculature.<\/p>\n<p>Clinical studies showed higher plasma levels of CCL11 in the patients who had brain fog.<\/p>\n<p>Hamster studies have showed that COVID-19 leads to IL-1\u03b2 and IL-6 expression within the hippocampus and medulla oblongata and is associated with decreased neurogenesis in the hippocampal dentate gyrus which leads to learning and memory deficits.<\/p>\n<p>This has also been shown in direct in vitro assays\u2014with application of serum from COVID-19 patients with delirium with elevated IL-6 leading to decreased proliferation and increased apoptosis of a human hippocampal progenitor cell line.<\/p>\n<p>&nbsp;<\/p>\n<p>Read more<a href=\"https:\/\/www.drknowhk.org\/wp-content\/uploads\/2024\/10\/fimmu-15-1440324.pdf\"> click here<\/a><\/p>","protected":false},"excerpt":{"rendered":"<p>\u5c0d\u4e0d\u8d77\uff0c\u6b64\u5185\u5bb9\u53ea\u9069\u7528\u65bcEnglish\u3002By Cordelia Dunai et al. Source Frontiers \u5fc3\u81df\u611f\u67d3\uff0c\u9059\u611f\u8166\u708e Latest findings suggest that a primarily pulmonary inflammatory process is rapidly associated with parainfectious immune activation in the brain and the signature of an NK cell and\/or T cell response which indicates a cascade of inflammation. Studies of brain organoids have reported that Iba1+ microglia engulf post-synaptic [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":14840,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[49,128,56,21,52],"tags":[],"class_list":["post-14839","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-brain-cancer-metabolic-syndrome-og","category-brain","category-evidence-based-research-in-western-medicine-clinical-practice","category-scientific-reports","category-virology-pathophysiology"],"_links":{"self":[{"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/posts\/14839","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/comments?post=14839"}],"version-history":[{"count":1,"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/posts\/14839\/revisions"}],"predecessor-version":[{"id":14842,"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/posts\/14839\/revisions\/14842"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/media\/14840"}],"wp:attachment":[{"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/media?parent=14839"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/categories?post=14839"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/tags?post=14839"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}