{"id":14877,"date":"2024-10-14T07:14:25","date_gmt":"2024-10-14T07:14:25","guid":{"rendered":"https:\/\/www.drknowhk.org\/?p=14877"},"modified":"2024-10-22T07:15:49","modified_gmt":"2024-10-22T07:15:49","slug":"integrated-multimodal-cell-atlas-of-alzheimers-disease-2","status":"publish","type":"post","link":"http:\/\/www.drknowhk.org\/mo\/integrated-multimodal-cell-atlas-of-alzheimers-disease-2\/","title":{"rendered":"Integrated multimodal cell atlas of Alzheimer\u2019s disease"},"content":{"rendered":"<p class=\"qtranxs-available-languages-message qtranxs-available-languages-message-mo\">\u5c0d\u4e0d\u8d77\uff0c\u6b64\u5185\u5bb9\u53ea\u9069\u7528\u65bc<a href=\"http:\/\/www.drknowhk.org\/en\/wp-json\/wp\/v2\/posts\/14877\" class=\"qtranxs-available-language-link qtranxs-available-language-link-en\" title=\"English\">English<\/a>\u3002<\/p><p>\u8a8d\u77e5\u969c\u7919 : \u5f9e\u4efd\u5b50\uff0c\u7d30\u80de\u5230\u75c5\u5fb5<\/p>\n<p>This cohort includes 33 male donors and 51 female donors, with an average age at time of death of 88 years. Researchers used quantitative neuropathology to place donors along a disease pseudoprogression score. Pseudoprogression analysis revealed two disease phases : an early phase with a slow increase in pathology, presence of inflammatory microglia, reactive astrocytes, loss of somatostatin+ inhibitory neurons, and a remyelination response by oligodendrocyte precursor cells; and a later phase with exponential increase in pathology, loss of excitatory neurons and Pvalb+ and Vip+ inhibitory neuron subtypes.<\/p>\n<p>&nbsp;<\/p>\n<p>Read more <a href=\"https:\/\/www.nature.com\/articles\/s41593-024-01774-5\">https:\/\/www.nature.com\/articles\/s41593-024-01774-5<\/a><\/p>","protected":false},"excerpt":{"rendered":"<p>\u5c0d\u4e0d\u8d77\uff0c\u6b64\u5185\u5bb9\u53ea\u9069\u7528\u65bcEnglish\u3002\u8a8d\u77e5\u969c\u7919 : \u5f9e\u4efd\u5b50\uff0c\u7d30\u80de\u5230\u75c5\u5fb5 This cohort includes 33 male donors and 51 female donors, with an average age at time of death of 88 years. Researchers used quantitative neuropathology to place donors along a disease pseudoprogression score. Pseudoprogression analysis revealed two disease phases : an early phase with a slow increase in pathology, presence of inflammatory [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":14879,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[49,128,33],"tags":[],"class_list":["post-14877","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-brain-cancer-metabolic-syndrome-og","category-brain","category-western-medicine"],"_links":{"self":[{"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/posts\/14877","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/comments?post=14877"}],"version-history":[{"count":1,"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/posts\/14877\/revisions"}],"predecessor-version":[{"id":14878,"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/posts\/14877\/revisions\/14878"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/media\/14879"}],"wp:attachment":[{"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/media?parent=14877"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/categories?post=14877"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/tags?post=14877"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}