{"id":15075,"date":"2024-11-12T07:35:11","date_gmt":"2024-11-12T07:35:11","guid":{"rendered":"https:\/\/www.drknowhk.org\/?p=15075"},"modified":"2024-11-15T07:38:22","modified_gmt":"2024-11-15T07:38:22","slug":"interleukin-1-prevents-sars-cov-2-induced-membrane-fusion-to-restrict-viral-transmission-via-induction-of-actin-bundles","status":"publish","type":"post","link":"http:\/\/www.drknowhk.org\/mo\/interleukin-1-prevents-sars-cov-2-induced-membrane-fusion-to-restrict-viral-transmission-via-induction-of-actin-bundles\/","title":{"rendered":"Interleukin-1 prevents SARS-CoV-2-induced membrane fusion to restrict viral transmission via induction of actin bundles"},"content":{"rendered":"<p class=\"qtranxs-available-languages-message qtranxs-available-languages-message-mo\">\u5c0d\u4e0d\u8d77\uff0c\u6b64\u5185\u5bb9\u53ea\u9069\u7528\u65bc<a href=\"http:\/\/www.drknowhk.org\/en\/wp-json\/wp\/v2\/posts\/15075\" class=\"qtranxs-available-language-link qtranxs-available-language-link-en\" title=\"English\">English<\/a>\u3002<\/p><p>By <span class=\"highwire-citation-authors\"><span class=\"highwire-citation-author first hw-author-orcid-logo-wrapper has-tooltip hasTooltip\" data-delta=\"0\" data-hasqtip=\"1\" aria-describedby=\"qtip-1\"><span class=\"nlm-given-names\">Xu<\/span> <span class=\"nlm-surname\">Zheng<\/span><\/span><\/span> et al.<\/p>\n<p>Source biorxiv<\/p>\n<p>Latest findings suggest that understanding how the immune system, particularly cytokines, can inhibit viral cell-cell fusion may be key to developing new strategies to combat COVID-19 and other viral diseases.<\/p>\n<p>Researchers found that immune cells release factors that can prevent the fusion of SARS-CoV-2-infected cells with neighboring cells, a process called syncytia formation. This is important because syncytia can help the virus spread more easily.<\/p>\n<p>One key factor identified was interleukin-1\u03b2 (IL-1\u03b2). IL-1\u03b2 was able to block syncytia formation by activating a signaling pathway that leads to the formation of actin bundles at the junctions between infected and uninfected cells.<\/p>\n<p>These actin bundles act as a physical barrier, preventing the cells from fusing.<\/p>\n<p>Interestingly, the researchers found that IL-1\u03b2 was able to inhibit syncytia formation induced by different variants of SARS-CoV-2, including Alpha, Beta, Delta, and Omicron.<\/p>\n<p>This suggests IL-1\u03b2 may be an important factor in the body&#8217;s defense against the virus, regardless of the specific variant.<\/p>\n<p>The study also showed that in mice, IL-1\u03b2 was able to significantly reduce the spread of SARS-CoV-2 in the lungs.<\/p>\n<p>This highlights the potential importance of cytokines like IL-1\u03b2 in controlling viral infection, beyond just their role in triggering inflammation.<\/p>\n<p>&nbsp;<\/p>\n<p>Read more<a href=\"https:\/\/www.drknowhk.org\/wp-content\/uploads\/2024\/11\/2024.05.16.594569v2.full_.pdf\"> click here<\/a><\/p>","protected":false},"excerpt":{"rendered":"<p>\u5c0d\u4e0d\u8d77\uff0c\u6b64\u5185\u5bb9\u53ea\u9069\u7528\u65bcEnglish\u3002By Xu Zheng et al. Source biorxiv Latest findings suggest that understanding how the immune system, particularly cytokines, can inhibit viral cell-cell fusion may be key to developing new strategies to combat COVID-19 and other viral diseases. Researchers found that immune cells release factors that can prevent the fusion of SARS-CoV-2-infected cells with neighboring cells, [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":15077,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[21,52],"tags":[],"class_list":["post-15075","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-scientific-reports","category-virology-pathophysiology"],"_links":{"self":[{"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/posts\/15075","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/comments?post=15075"}],"version-history":[{"count":1,"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/posts\/15075\/revisions"}],"predecessor-version":[{"id":15078,"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/posts\/15075\/revisions\/15078"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/media\/15077"}],"wp:attachment":[{"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/media?parent=15075"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/categories?post=15075"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/tags?post=15075"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}