{"id":15239,"date":"2024-12-14T08:48:44","date_gmt":"2024-12-14T08:48:44","guid":{"rendered":"https:\/\/www.drknowhk.org\/?p=15239"},"modified":"2024-12-17T08:51:54","modified_gmt":"2024-12-17T08:51:54","slug":"homing-in-on-anthracyclines-high-risk-niche-in-early-breast-cancer","status":"publish","type":"post","link":"http:\/\/www.drknowhk.org\/mo\/homing-in-on-anthracyclines-high-risk-niche-in-early-breast-cancer\/","title":{"rendered":"Homing in on Anthracyclines&#8217; High-Risk Niche in Early Breast Cancer"},"content":{"rendered":"<p class=\"qtranxs-available-languages-message qtranxs-available-languages-message-mo\">\u5c0d\u4e0d\u8d77\uff0c\u6b64\u5185\u5bb9\u53ea\u9069\u7528\u65bc<a href=\"http:\/\/www.drknowhk.org\/en\/wp-json\/wp\/v2\/posts\/15239\" class=\"qtranxs-available-language-link qtranxs-available-language-link-en\" title=\"English\">English<\/a>\u3002<\/p><p>By Charles Bankhead<\/p>\n<p>Source Medpagetoday<\/p>\n<p>SAN ANTONIO &#8212; Women with larger, genomically high-risk breast cancers had significantly lower risk of distant metastasis with chemotherapy that included an anthracycline, a new analysis of a randomized trial showed.<\/p>\n<p>Patients with a 21-gene assay score \u226531 had a 68% reduction in the risk of distant metastasis at 5 years when their chemotherapy included an anthracycline (such as doxorubicin). Distant relapse-free survival (DRFS) and overall survival (OS) also favored anthracycline-containing chemotherapy but did reach statistical significance. The magnitude of benefit increased with risk scores out to 50.<\/p>\n<p>A subgroup analysis showed that the benefit in high-risk patients was limited to those with tumors &gt;2 cm, reported Nan Chen, MD, of the University of Chicago, at the San Antonio Breast Cancer Symposiumopens in a new tab or window (SABCS).<\/p>\n<p>&#8220;Anthracyclines should be considered in patients with high genomic-risk, hormone receptor-positive [HR+], node-negative disease,&#8221; she concluded.<\/p>\n<p>&nbsp;<\/p>\n<p>Read more <a href=\"https:\/\/www.medpagetoday.com\/meetingcoverage\/sabcs\/113395\">https:\/\/www.medpagetoday.com\/meetingcoverage\/sabcs\/113395<\/a><\/p>\n<p>&nbsp;<\/p>","protected":false},"excerpt":{"rendered":"<p>\u5c0d\u4e0d\u8d77\uff0c\u6b64\u5185\u5bb9\u53ea\u9069\u7528\u65bcEnglish\u3002By Charles Bankhead Source Medpagetoday SAN ANTONIO &#8212; Women with larger, genomically high-risk breast cancers had significantly lower risk of distant metastasis with chemotherapy that included an anthracycline, a new analysis of a randomized trial showed. Patients with a 21-gene assay score \u226531 had a 68% reduction in the risk of distant metastasis at 5 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":15215,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[47,129,33],"tags":[],"class_list":["post-15239","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-cancer","category-cancer-pages","category-western-medicine"],"_links":{"self":[{"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/posts\/15239","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/comments?post=15239"}],"version-history":[{"count":1,"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/posts\/15239\/revisions"}],"predecessor-version":[{"id":15240,"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/posts\/15239\/revisions\/15240"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/media\/15215"}],"wp:attachment":[{"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/media?parent=15239"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/categories?post=15239"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/tags?post=15239"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}