<\/p>\n
Didier Raoult<\/a><\/strong><\/p>\n The paper that appears to have triggered the Trump administration\u2019s obsession with hydroxychloroquine as a treatment for infection with the novel coronavirus has received a statement of concern from the society that publishes the journal in which the work appeared.<\/p>\n The April 3, 2020,\u00a0notice<\/a><\/strong>, from the\u00a0International Journal of Antimicrobial Agents<\/em>, states that the March 20 article, \u201cHydroxychloroquine and azithromycin as a treatment of Covid-19: results of an open-label non-randomized clinical trial<\/strong><\/a>\u201d<\/p>\n The notice, which is from the ISAC and not the journal itself, is a bit ambiguous. The society says it \u201cshares the concerns\u201d about the paper, but it doesn\u2019t appear to be taking additional action.<\/p>\n The study was led by Didier Raoult, of the University of Marseille, whose publication history has come under\u00a0scrutiny<\/a><\/strong>.<\/p>\n Last month, Elisabeth Bik took a\u00a0close look<\/a><\/strong>\u00a0at the\u00a0IJAA\u00a0<\/em>article and detailed a long list of serious problems with the study, including questions about its ethical underpinnings, messy confounding variables, missing patients, rushed and conflicted peer review, and confusing data.<\/p>\n Others have used\u00a0PubPeer\u00a0<\/a><\/strong>to report additional issues with the Raoult article.<\/p>\n Raoult has not responded to a request for comment from Retraction Watch.<\/p>\n Of course, the horse has left the proverbial barn on this one. An untold number of patients have been receiving hydroxychloroquine, as well as chloroquine, for Covid-19 infection, thanks in large part to cheerleading for the drugs from President Trump.<\/p>\n lthough a certain amount of haste is to be expected in a medical crisis, and sometimes spitballing may be a viable option, the use of poorly investigated therapies is hardly risk free. In this case, not only do the drugs carry significant side effects, but they are critical treatments for people with lupus and rheumatoid arthritis \u2014 patients who now have to hope that they can still get access to medications that are keeping them alive. (Now come reports that\u00a0states are hoarding<\/a>\u00a0<\/strong>hydroxychloroquine and chloroquine for precisely these people.)<\/p>\n In other words, although the president might be narrowly correct when he says that Covid-19 patients have \u201cnothing to lose<\/a><\/strong>\u201d by taking the drugs, the game is zero-sum.<\/p>\n And we are likely to see lots of \u201cpromising\u201d but ultimately unhelpful treatments in the days and weeks ahead.\u00a0As we wrote the other day in\u00a0Wired<\/a><\/strong>:<\/p>\n Update, 1900 UTC, 4\/12\/20: Elsevier is now\u00a0investigating the paper<\/a><\/strong>. Didier Raoult The paper that appears to have triggered the Trump administration\u2019s obsession with hydroxychloroquine as a treatment for infection with the novel coronavirus has received a statement of concern from the society that publishes the journal in which the work appeared. The April 3, 2020,\u00a0notice, from the\u00a0International Journal of Antimicrobial Agents, states that […]<\/p>\n","protected":false},"author":1,"featured_media":2487,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[57],"tags":[],"class_list":["post-8448","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-expert-commentary-announcement"],"_links":{"self":[{"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/posts\/8448","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/comments?post=8448"}],"version-history":[{"count":1,"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/posts\/8448\/revisions"}],"predecessor-version":[{"id":8449,"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/posts\/8448\/revisions\/8449"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/media\/2487"}],"wp:attachment":[{"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/media?parent=8448"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/categories?post=8448"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/tags?post=8448"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}\n
does not meet the [International Society of Antimicrobial Chemotherapy\u2019s] expected standard, especially relating to the lack of better explanations of the inclusion criteria and the triage of patients to ensure patient safety.<\/em><\/h6>\n<\/blockquote>\n
\n
When it comes to findings, the Covid-19 train is an express, while the rigorous science coach is a local. Until that local arrives at its final destination, it may be wise to label all this research\u2014preprints, peer-reviewed papers, and for goodness\u2019 sake, pronouncements from Donald Trump\u2014 with a black-box warning: \u201cThere is some evidence for this now. It will likely turn out to be at least partially wrong.\u201d<\/em><\/h6>\n<\/blockquote>\n
\n\u985e\u578b: \u6587\u7ae0
\n\u4f5c\u8005: Adam Marcus
\n\u51fa\u8655: Retraction Watch
\n\u9023\u7d50: https:\/\/retractionwatch.com\/2020\/04\/06\/hydroxychlorine-covid-19-study-did-not-meet-publishing-societys-expected-standard\/<\/a>
\n<\/p>","protected":false},"excerpt":{"rendered":"