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Lianhua Qingwen is a traditional Chinese medicine, which has been reported to be effective in the treatment of pneumonia. However, no consensus has been reached; therefore, we aimed to provide reliable assessments of common pneumonia and COVID-19 pneumonia.

Our findings suggest that LHQW may inhibit the lipopolysaccharide-mediated inflammatory response and regulate the AGE-RAGE signaling pathway through IL6. In addition, the N-terminal domain of the S protein of COVID-19 has a good binding activity to IL6ST, and quercetin and wogonin in LHQW may affect IL6ST-mediated IL6 signal transduction and a large number of signaling pathways downstream to other cytokines by directly affecting protein-protein interaction. These findings suggest the potential molecular mechanism by which LHQW inhibits COVID-19 through the regulation of IL6R/IL6/IL6ST.

The PowerPoint include brief summaries of a series of studies about Lianhuaqingwen in Covid 19 treatment