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Shu-Feng-Jie-Du Capsules (SFJDCs) have been clinically proven to have a good therapeutic effect on COVID-19 in China. This study aimed to analyze the common mechanisms of SFJDC in the treatment of severe acute respiratory syndrome (SARS), Middle East respiratory syndrome (MERS), and COVID-19 via network pharmacology and molecular docking. We further explored the potential application value of SFJDC in the treatment of coronavirus infection. Unlike the previous single-target and single-pathway mechanism research, network pharmacology conforms to the systemic and holistic thinking mode of Chinese medicine. The high- throughput molecular docking technique can simulate interactions between receptors and drug molecules. It is usually used to study the active sites of drugs and plays an important role in the study of natural products. In this study, we predicted the core components and core targets of SFJDC and the signaling pathways for treatment of SARS, MERS, and COVID-19 through network pharmacology and molecular docking, and the common effects and mechanisms of SFJDC in the treatment of these 3 kinds of CoV infection are discussed.