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The coronavirus disease, 2019 (COVID-19), has spread rapidly around the world and become a major public health problem facing the world. Traditional Chinese medicine (TCM) has been fully committed to treat COVID-19 in China. It improved the clinical symptoms of patients and reduced the mortality rate. In light of the fever was identified as one of leading clinical features of COVID-19, this paper will first analyze the material basis of fever, then the humoral and neural pathways of fever signal transmission will be described. Finally, combining with the chemical composition and pharmacological action of available TCM, we analyzed the mechanisms of TCMs to play the antipyretic effect through multiple ways. So as to further provide the basis for the research of antipyretic compound preparations of TCMs and explore the potential medicines for the prevention and treatment of COVID-19.

Previous systematic reviews indicated that CM formulae combined with Western medi- cine significantly improved the clinical symptoms compared with Western medicine alone (Wang et al., 2021a; Yin et al., 2021; Zhou et al., 2021a). However, the definitive conclu- sion was not reached due to the heterogeneity of pooled studies and a small number of eligible studies. As more studies are published, the systematic reviews need to be updated. Particularly, these newly published studies followed China’s guidelines for treatment and diagnosis of COVID-19, which might reduce the heterogeneity among studies. Our study aimed to systematically review the current clinical studies on each CM formula for COVID-19 treatment.