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Neurodegenerative diseases (NDs) are common chronic diseases related to progressive damage of the nervous system. Globally, the number of people with an ND is dramatically increasing consistent with the fast aging of society and one of the common features of NDs is the abnormal aggregation of diverse proteins. Autophagy is the main process by which misfolded proteins and damaged organelles are removed from cells. It has been found that the impairment of autophagy is associated with many NDs, suggesting that autophagy has a vital role in the neurodegeneration process. Recently, more and more studies have reported that autophagy inducers display a protective role in different ND experimental models, suggesting that enhancement of autophagy could be a potential therapy for NDs. In this review, the evidence for beneficial effects of traditional Chinese medicine (TCM) regulate autophagy in the models of Alzheimer’s disease (AD), Parkinson’s disease (PD), and other NDs are presented and common autophagy-related mechanisms are identified. The results demonstrate that TCM which regulate autophagy are potential therapeutic candidates for ND treatment.

Since the outbreak of novel coronavirus pneumonia (COVID-19) in December 2019, more than 2,500,000 people worldwide have been diagnosed with SARS-CoV-2 as of April 22. In response to this epidemic, China has issued seven trial versions of diagnosis and treatment protocol for COVID-19. According to the information that we have collected so far, this article provides an overview of potential therapeutic drugs and compounds with much attention, including favipiravir and hydroxychloroquine, as well as traditional Chinese medicine, which have been reported with good clinical treatment effects. Moreover, with further understanding of SARS-CoV-2 virus, new drugs targeting specific SARS-CoV-2 viral components arise and investigations on these novel anti-SARS-CoV-2 agents are also reviewed.

近日，由成都中医药大学附属医院(四川省中医院)新冠肺炎应急攻关课题组完成的我国首个中医药社区防控新冠肺炎临床研究成果“Effects and Safety of Herbal Medicines among Community-dwelling Residents during COVID-19 Pandemic: A Large Prospective, Randomized Controlled Trial (RCT)”在国际药学1区杂志《Phytomedicine》（2020年中科院SCI期刊分区）刊出。这是继钟南山院士团队在该期刊发表莲花清瘟治疗新冠肺炎临床试验结果后，第二篇在该期刊发表的中医药防治新冠肺炎循证证据，也是国际上第一篇有关研究新冠疫情期间中医药社区人群防控方面的文章⋯⋯

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