{"id":12822,"date":"2024-05-03T14:12:51","date_gmt":"2024-05-03T14:12:51","guid":{"rendered":"https:\/\/www.drknowhk.org\/?p=12822"},"modified":"2024-06-26T14:15:23","modified_gmt":"2024-06-26T14:15:23","slug":"plasma-leptin-and-alzheimer-protein-pathologies-among-older-adults","status":"publish","type":"post","link":"https:\/\/www.drknowhk.org\/mo\/plasma-leptin-and-alzheimer-protein-pathologies-among-older-adults\/","title":{"rendered":"Plasma Leptin and Alzheimer Protein Pathologies Among Older Adults"},"content":{"rendered":"<p class=\"qtranxs-available-languages-message qtranxs-available-languages-message-mo\">\u5c0d\u4e0d\u8d77\uff0c\u6b64\u5185\u5bb9\u53ea\u9069\u7528\u65bc<a href=\"https:\/\/www.drknowhk.org\/en\/wp-json\/wp\/v2\/posts\/12822\" class=\"qtranxs-available-language-link qtranxs-available-language-link-en\" title=\"English\">English<\/a>\u3002<\/p><p>By Seunghoon Lee et al.<\/p>\n<p>Soure:jamanetwork<\/p>\n<p><strong>Question<\/strong>\u00a0\u00a0Are plasma leptin levels associated with baseline and longitudinal changes of the 2 key protein pathologies of Alzheimer disease (AD), amyloid-beta (A\u03b2) and tau deposition, as measured by positron emission tomography among cognitively normal older adults?<\/p>\n<p><strong>Findings<\/strong>\u00a0\u00a0In this cohort study of 208 cognitively normal older adults, lower plasma leptin levels had a significant cross-sectional association with greater brain A\u03b2 deposition and a significant longitudinal association with greater increase of brain tau deposition over 2 years.<\/p>\n<p>Read more <a href=\"https:\/\/jamanetwork.com\/journals\/jamanetworkopen\/fullarticle\/2818244\">https:\/\/jamanetwork.com\/journals\/jamanetworkopen\/fullarticle\/2818244<\/a><\/p>\n<p>&nbsp;<\/p>","protected":false},"excerpt":{"rendered":"<p>\u5c0d\u4e0d\u8d77\uff0c\u6b64\u5185\u5bb9\u53ea\u9069\u7528\u65bcEnglish\u3002By Seunghoon Lee et al. Soure:jamanetwork Question\u00a0\u00a0Are plasma leptin levels associated with baseline and longitudinal changes of the 2 key protein pathologies of Alzheimer disease (AD), amyloid-beta (A\u03b2) and tau deposition, as measured by positron emission tomography among cognitively normal older adults? Findings\u00a0\u00a0In this cohort study of 208 cognitively normal older adults, lower plasma leptin [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":12811,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[49],"tags":[],"class_list":["post-12822","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-brain-cancer-metabolic-syndrome-og"],"_links":{"self":[{"href":"https:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/posts\/12822","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/comments?post=12822"}],"version-history":[{"count":1,"href":"https:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/posts\/12822\/revisions"}],"predecessor-version":[{"id":12823,"href":"https:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/posts\/12822\/revisions\/12823"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/media\/12811"}],"wp:attachment":[{"href":"https:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/media?parent=12822"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/categories?post=12822"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/tags?post=12822"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}