{"id":13938,"date":"2024-06-29T13:56:27","date_gmt":"2024-06-29T13:56:27","guid":{"rendered":"https:\/\/www.drknowhk.org\/?p=13938"},"modified":"2024-08-15T14:02:21","modified_gmt":"2024-08-15T14:02:21","slug":"evolutionary-dynamics-and-comparative-pathogenicity-of-clade-2-3-4-4b-h5-subtype-avian-influenza-viruses-china-2021-2022","status":"publish","type":"post","link":"https:\/\/www.drknowhk.org\/mo\/evolutionary-dynamics-and-comparative-pathogenicity-of-clade-2-3-4-4b-h5-subtype-avian-influenza-viruses-china-2021-2022\/","title":{"rendered":"Evolutionary dynamics and comparative pathogenicity of clade 2.3.4.4b H5 subtype avian influenza viruses, China, 2021\u20132022"},"content":{"rendered":"<p class=\"qtranxs-available-languages-message qtranxs-available-languages-message-mo\">\u5c0d\u4e0d\u8d77\uff0c\u6b64\u5185\u5bb9\u53ea\u9069\u7528\u65bc<a href=\"https:\/\/www.drknowhk.org\/en\/wp-json\/wp\/v2\/posts\/13938\" class=\"qtranxs-available-language-link qtranxs-available-language-link-en\" title=\"English\">English<\/a>\u3002<\/p><p>By <span class=\"given-name\">Siru<\/span>\u00a0<span class=\"text surname\">Lin et al.<\/span><\/p>\n<p>Source sciencedirect<\/p>\n<h2 class=\"section-title u-h4 u-margin-l-top u-margin-xs-bottom\">Abstract<\/h2>\n<div id=\"abssec0010\">\n<p id=\"abspara0010\">The recent concurrent emergence of\u00a0H5N1, H5N6, and\u00a0H5N8\u00a0avian influenza\u00a0viruses (AIVs) has led to significant avian mortality globally. Since 2020, frequent human-animal interactions have been documented. To gain insight into the novel H5 subtype AIVs (i.e.,\u00a0H5N1, H5N6 and H5N8), we collected 6102 samples from various regions of China between January 2021 and September 2022, and identified 41 H5Nx strains. Comparative analyses on the evolution and biological properties of these isolates were conducted.\u00a0Phylogenetic analysis\u00a0revealed that the 41 H5Nx strains belonged to clade 2.3.4.4b, with 13 related to\u00a0H5N1, 19 to H5N6, and 9 to H5N8. Analysis based on global 2.3.4.4b viruses showed that all the viruses described in this study were likely originated from H5N8, exhibiting a heterogeneous evolutionary history between H5N1 and H5N6 during 2015\u20132022 worldwide. H5N1 showed a higher rate of evolution in 2021\u20132022 and more sites under positive selection pressure in 2015\u20132022.<\/p>\n<p>Read more <a href=\"https:\/\/www.drknowhk.org\/wp-content\/uploads\/2024\/08\/1-s2.0-S1995820X24000609-main.pdf\">click here<\/a><\/p>\n<p>&nbsp;<\/p>\n<\/div>\n<p><\/p>","protected":false},"excerpt":{"rendered":"<p>\u5c0d\u4e0d\u8d77\uff0c\u6b64\u5185\u5bb9\u53ea\u9069\u7528\u65bcEnglish\u3002By Siru\u00a0Lin et al. Source sciencedirect Abstract The recent concurrent emergence of\u00a0H5N1, H5N6, and\u00a0H5N8\u00a0avian influenza\u00a0viruses (AIVs) has led to significant avian mortality globally. Since 2020, frequent human-animal interactions have been documented. To gain insight into the novel H5 subtype AIVs (i.e.,\u00a0H5N1, H5N6 and H5N8), we collected 6102 samples from various regions of China between January [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":13940,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[56,21],"tags":[],"class_list":["post-13938","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-evidence-based-research-in-western-medicine-clinical-practice","category-scientific-reports"],"_links":{"self":[{"href":"https:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/posts\/13938","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/comments?post=13938"}],"version-history":[{"count":1,"href":"https:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/posts\/13938\/revisions"}],"predecessor-version":[{"id":13941,"href":"https:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/posts\/13938\/revisions\/13941"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/media\/13940"}],"wp:attachment":[{"href":"https:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/media?parent=13938"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/categories?post=13938"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/tags?post=13938"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}