{"id":13950,"date":"2024-04-26T14:29:23","date_gmt":"2024-04-26T14:29:23","guid":{"rendered":"https:\/\/www.drknowhk.org\/?p=13950"},"modified":"2024-08-15T14:40:43","modified_gmt":"2024-08-15T14:40:43","slug":"an-amyloidogenic-fragment-of-the-sars-cov-2-envelope-protein-promotes-serum-amyloid-a-misfolding-and-fibrillization","status":"publish","type":"post","link":"https:\/\/www.drknowhk.org\/mo\/an-amyloidogenic-fragment-of-the-sars-cov-2-envelope-protein-promotes-serum-amyloid-a-misfolding-and-fibrillization\/","title":{"rendered":"An amyloidogenic fragment of the SARS CoV-2 envelope protein promotes serum amyloid A misfolding and fibrillization"},"content":{"rendered":"<p class=\"qtranxs-available-languages-message qtranxs-available-languages-message-mo\">\u5c0d\u4e0d\u8d77\uff0c\u6b64\u5185\u5bb9\u53ea\u9069\u7528\u65bc<a href=\"https:\/\/www.drknowhk.org\/en\/wp-json\/wp\/v2\/posts\/13950\" class=\"qtranxs-available-language-link qtranxs-available-language-link-en\" title=\"English\">English<\/a>\u3002<\/p><p>By Asal Nady et al.<\/p>\n<p>Source biorxiv<\/p>\n<h2 class=\"\">ABSTRACT<\/h2>\n<p id=\"p-2\">SARS CoV-2 infection can affect a surprising number of organs in the body and cause symptoms such as abnormal blood coagulation, fibrinolytic disturbances, and neurodegeneration. Our study delves into the intricate pathogenic potential of a SARS-CoV-2 envelope protein peptide, shedding light on its implications for multi-organ effects and amyloid formation. Specifically, we focus on the peptide SK9 or\u00a0<sup>54<\/sup>SFYVYSRVK<sup>62<\/sup>\u00a0derived from the C-terminus of human SARS coronavirus 2 envelope protein. We demonstrate that SK9 containing peptides readily form classic amyloid structures consistent with predictions of amyloid aggregation algorithms.\u00a0<em>In vivo<\/em>, overexpression of proteases such as neutrophil elastase during inflammation can potentially lead to C-terminal peptides containing SK9.<\/p>\n<p>Read more <a href=\"https:\/\/www.drknowhk.org\/wp-content\/uploads\/2024\/08\/2024.04.25.591137v1.full_.pdf\">click here<\/a><\/p>\n<p>&nbsp;<\/p>","protected":false},"excerpt":{"rendered":"<p>\u5c0d\u4e0d\u8d77\uff0c\u6b64\u5185\u5bb9\u53ea\u9069\u7528\u65bcEnglish\u3002By Asal Nady et al. Source biorxiv ABSTRACT SARS CoV-2 infection can affect a surprising number of organs in the body and cause symptoms such as abnormal blood coagulation, fibrinolytic disturbances, and neurodegeneration. Our study delves into the intricate pathogenic potential of a SARS-CoV-2 envelope protein peptide, shedding light on its implications for multi-organ effects [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":13952,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[52],"tags":[],"class_list":["post-13950","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-virology-pathophysiology"],"_links":{"self":[{"href":"https:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/posts\/13950","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/comments?post=13950"}],"version-history":[{"count":2,"href":"https:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/posts\/13950\/revisions"}],"predecessor-version":[{"id":13954,"href":"https:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/posts\/13950\/revisions\/13954"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/media\/13952"}],"wp:attachment":[{"href":"https:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/media?parent=13950"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/categories?post=13950"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/tags?post=13950"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}