{"id":14158,"date":"2024-07-23T08:59:11","date_gmt":"2024-07-23T08:59:11","guid":{"rendered":"https:\/\/www.drknowhk.org\/?p=14158"},"modified":"2024-08-26T09:11:31","modified_gmt":"2024-08-26T09:11:31","slug":"long-term-risk-of-autoimmune-diseases-after-mrna-based-sars-cov2-vaccination-in-a-korean-nationwide-population-based-cohort-study","status":"publish","type":"post","link":"https:\/\/www.drknowhk.org\/mo\/long-term-risk-of-autoimmune-diseases-after-mrna-based-sars-cov2-vaccination-in-a-korean-nationwide-population-based-cohort-study\/","title":{"rendered":"Long-term risk of autoimmune diseases after mRNA-based SARS-CoV2 vaccination in a Korean, nationwide, population-based cohort study"},"content":{"rendered":"<p class=\"qtranxs-available-languages-message qtranxs-available-languages-message-mo\">\u5c0d\u4e0d\u8d77\uff0c\u6b64\u5185\u5bb9\u53ea\u9069\u7528\u65bc<a href=\"https:\/\/www.drknowhk.org\/en\/wp-json\/wp\/v2\/posts\/14158\" class=\"qtranxs-available-language-link qtranxs-available-language-link-en\" title=\"English\">English<\/a>\u3002<\/p><p>By Seung-Won Jung et al.<\/p>\n<p>Source Nature<\/p>\n<section lang=\"en\" aria-labelledby=\"Abs1\" data-title=\"Abstract\">\n<div id=\"Abs1-section\" class=\"c-article-section\">\n<h2 id=\"Abs1\" class=\"c-article-section__title js-section-title js-c-reading-companion-sections-item\">Abstract<\/h2>\n<div id=\"Abs1-content\" class=\"c-article-section__content\">\n<p>The long-term association between mRNA-based coronavirus disease 2019 (COVID-19) vaccination and the development of autoimmune connective tissue diseases (AI-CTDs) remains unclear. In this nationwide, population-based cohort study involving 9,258,803 individuals, we aim to determine whether the incidence of AI-CTDs is associated with mRNA vaccination. The study spans over 1 year of observation and further analyses the risk of AI-CTDs by stratifying demographics and vaccination profiles and treating booster vaccination as time-varying covariate. We report that the risk of developing most AI-CTDs did not increase following mRNA vaccination, except for systemic lupus erythematosus with a 1.16-fold risk in vaccinated individuals relative to controls. Comparable results were reported in the stratified analyses for age, sex, mRNA vaccine type, and prior history of non-mRNA vaccination. However, a booster vaccination was associated with an increased risk of some AI-CTDs including alopecia areata, psoriasis, and rheumatoid arthritis. Overall, we conclude that mRNA-based vaccinations are not associated with an increased risk of most AI-CTDs, although further research is needed regarding its potential association with certain conditions.<\/p>\n<p>Read more <a href=\"https:\/\/www.drknowhk.org\/wp-content\/uploads\/2024\/08\/s41467-024-50656-8.pdf\">click here<\/a><\/p>\n<\/div>\n<\/div>\n<\/section>\n<p><\/p>","protected":false},"excerpt":{"rendered":"<p>\u5c0d\u4e0d\u8d77\uff0c\u6b64\u5185\u5bb9\u53ea\u9069\u7528\u65bcEnglish\u3002By Seung-Won Jung et al. Source Nature Abstract The long-term association between mRNA-based coronavirus disease 2019 (COVID-19) vaccination and the development of autoimmune connective tissue diseases (AI-CTDs) remains unclear. In this nationwide, population-based cohort study involving 9,258,803 individuals, we aim to determine whether the incidence of AI-CTDs is associated with mRNA vaccination. The study spans [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":14160,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[56,90,21],"tags":[],"class_list":["post-14158","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-evidence-based-research-in-western-medicine-clinical-practice","category-long-covid19","category-scientific-reports"],"_links":{"self":[{"href":"https:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/posts\/14158","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/comments?post=14158"}],"version-history":[{"count":1,"href":"https:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/posts\/14158\/revisions"}],"predecessor-version":[{"id":14161,"href":"https:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/posts\/14158\/revisions\/14161"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/media\/14160"}],"wp:attachment":[{"href":"https:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/media?parent=14158"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/categories?post=14158"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/tags?post=14158"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}