{"id":14692,"date":"2024-05-31T09:12:27","date_gmt":"2024-05-31T09:12:27","guid":{"rendered":"https:\/\/www.drknowhk.org\/?p=14692"},"modified":"2024-10-08T09:18:55","modified_gmt":"2024-10-08T09:18:55","slug":"biophysical-principles-predict-fitness-of-sars-cov-2-variants","status":"publish","type":"post","link":"https:\/\/www.drknowhk.org\/mo\/biophysical-principles-predict-fitness-of-sars-cov-2-variants\/","title":{"rendered":"Biophysical principles predict fitness of SARS-CoV-2 variants"},"content":{"rendered":"<p class=\"qtranxs-available-languages-message qtranxs-available-languages-message-mo\">\u5c0d\u4e0d\u8d77\uff0c\u6b64\u5185\u5bb9\u53ea\u9069\u7528\u65bc<a href=\"https:\/\/www.drknowhk.org\/en\/wp-json\/wp\/v2\/posts\/14692\" class=\"qtranxs-available-language-link qtranxs-available-language-link-en\" title=\"English\">English<\/a>\u3002<\/p><p>By <span class=\"authors\"><span role=\"list\"><span role=\"listitem\">Dianzhuo Wang<\/span><\/span><\/span> et al.<\/p>\n<p>Source PNAS<\/p>\n<section id=\"executive-summary-abstract\" role=\"doc-abstract\">\n<h2>Significance<\/h2>\n<div role=\"paragraph\">This research presents a biophysical model that maps the molecular properties of SARS-CoV-2\u2019s receptor binding domain into an epistatic fitness landscape. By linking the binding affinities of the virus to its epidemic fitness, we offer a powerful tool for understanding and predicting the emergence and success of new viral variants. Our model, validated with real-world data and informed by theoretical insights, provides a foundation for interpreting the evolutionary trajectory of past pandemics and predicting those of the future. The adaptability of this biophysical model extends to the key proteins of other viruses as well, signifying its potential in guiding public health interventions, and advancing our understanding of viral evolution.<\/div>\n<\/section>\n<div role=\"paragraph\"><\/div>\n<div role=\"paragraph\"><\/div>\n<div role=\"paragraph\">Read more <a href=\"https:\/\/www.drknowhk.org\/wp-content\/uploads\/2024\/10\/wang-et-al-2024-biophysical-principles-predict-fitness-of-sars-cov-2-variants-1.pdf\">click here <\/a><\/div>\n<p>&nbsp;<\/p>","protected":false},"excerpt":{"rendered":"<p>\u5c0d\u4e0d\u8d77\uff0c\u6b64\u5185\u5bb9\u53ea\u9069\u7528\u65bcEnglish\u3002By Dianzhuo Wang et al. Source PNAS Significance This research presents a biophysical model that maps the molecular properties of SARS-CoV-2\u2019s receptor binding domain into an epistatic fitness landscape. By linking the binding affinities of the virus to its epidemic fitness, we offer a powerful tool for understanding and predicting the emergence and success of [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":14694,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[21,52],"tags":[],"class_list":["post-14692","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-scientific-reports","category-virology-pathophysiology"],"_links":{"self":[{"href":"https:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/posts\/14692","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/comments?post=14692"}],"version-history":[{"count":1,"href":"https:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/posts\/14692\/revisions"}],"predecessor-version":[{"id":14695,"href":"https:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/posts\/14692\/revisions\/14695"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/media\/14694"}],"wp:attachment":[{"href":"https:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/media?parent=14692"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/categories?post=14692"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/tags?post=14692"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}