{"id":14996,"date":"2022-08-24T08:24:23","date_gmt":"2022-08-24T08:24:23","guid":{"rendered":"https:\/\/www.drknowhk.org\/?p=14996"},"modified":"2024-11-08T08:29:46","modified_gmt":"2024-11-08T08:29:46","slug":"degradative-effect-of-nattokinase-on-spike-protein-of-sars-cov-2","status":"publish","type":"post","link":"https:\/\/www.drknowhk.org\/mo\/degradative-effect-of-nattokinase-on-spike-protein-of-sars-cov-2\/","title":{"rendered":"Degradative Effect of Nattokinase on Spike Protein of SARS-CoV-2"},"content":{"rendered":"<p class=\"qtranxs-available-languages-message qtranxs-available-languages-message-mo\">\u5c0d\u4e0d\u8d77\uff0c\u6b64\u5185\u5bb9\u53ea\u9069\u7528\u65bc<a href=\"https:\/\/www.drknowhk.org\/en\/wp-json\/wp\/v2\/posts\/14996\" class=\"qtranxs-available-language-link qtranxs-available-language-link-en\" title=\"English\">English<\/a>\u3002<\/p><p>By Takashi Tanikawa et al.<\/p>\n<p>Source MDPI<\/p>\n<p>\u65e5\u672c\u7d0d\u8c46\uff0c\u6297\u6bd2\u4f73\u97f3<br \/>\nNatto extract has<br \/>\nbeen reported to inhibit SARS-CoV-2 infection in Vero E6 cells via RBD degradation. Researchers demonstrated that S protein degradation by nattokinase was blocked by heat or protein-inhibitor treatments. Our data suggest that the protease activity of nattokinase plays a<br \/>\ncrucial role in S protein degradation. Taken together, these findings support the notion that the inhibition of SARS-CoV-2 infection by natto extract was due to S protein degradation by nattokinase. Thus, our data indicated that nattokinase and natto extracts have potential effects on the inhibition of SARS-CoV-2 host cell entry via S protein degradation.<\/p>\n<p>Read more<a href=\"https:\/\/www.drknowhk.org\/wp-content\/uploads\/2024\/11\/Degradative_Effect_of_Nattokinase_on_Spike_Protein.pdf\"> click here<\/a><\/p>","protected":false},"excerpt":{"rendered":"<p>\u5c0d\u4e0d\u8d77\uff0c\u6b64\u5185\u5bb9\u53ea\u9069\u7528\u65bcEnglish\u3002By Takashi Tanikawa et al. Source MDPI \u65e5\u672c\u7d0d\u8c46\uff0c\u6297\u6bd2\u4f73\u97f3 Natto extract has been reported to inhibit SARS-CoV-2 infection in Vero E6 cells via RBD degradation. Researchers demonstrated that S protein degradation by nattokinase was blocked by heat or protein-inhibitor treatments. Our data suggest that the protease activity of nattokinase plays a crucial role in S protein [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":14998,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[54,21,52],"tags":[],"class_list":["post-14996","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-research-materials-on-influenza-and-coronaviral-prevention-and-treatment","category-scientific-reports","category-virology-pathophysiology"],"_links":{"self":[{"href":"https:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/posts\/14996","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/comments?post=14996"}],"version-history":[{"count":1,"href":"https:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/posts\/14996\/revisions"}],"predecessor-version":[{"id":14999,"href":"https:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/posts\/14996\/revisions\/14999"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/media\/14998"}],"wp:attachment":[{"href":"https:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/media?parent=14996"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/categories?post=14996"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/tags?post=14996"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}