{"id":15351,"date":"2025-09-02T08:22:07","date_gmt":"2025-09-02T08:22:07","guid":{"rendered":"https:\/\/www.drknowhk.org\/?p=15351"},"modified":"2025-09-04T08:37:14","modified_gmt":"2025-09-04T08:37:14","slug":"%e5%a4%a9%e7%84%b6%e4%ba%a7%e7%89%a9%e6%b2%bb%e7%96%97%e4%bb%a3%e8%b0%a2%e6%80%a7%e7%9b%b8%e5%85%b3%e8%82%9d%e7%97%85%ef%bc%88%e9%9d%9e%e9%85%92%e7%b2%be%e6%80%a7%e8%84%82%e8%82%aa%e8%82%9d%ef%bc%89","status":"publish","type":"post","link":"https:\/\/www.drknowhk.org\/mo\/%e5%a4%a9%e7%84%b6%e4%ba%a7%e7%89%a9%e6%b2%bb%e7%96%97%e4%bb%a3%e8%b0%a2%e6%80%a7%e7%9b%b8%e5%85%b3%e8%82%9d%e7%97%85%ef%bc%88%e9%9d%9e%e9%85%92%e7%b2%be%e6%80%a7%e8%84%82%e8%82%aa%e8%82%9d%ef%bc%89\/","title":{"rendered":"\u5929\u7136\u4ea7\u7269\u6cbb\u7597\u4ee3\u8c22\u6027\u76f8\u5173\u809d\u75c5\uff08\u975e\u9152\u7cbe\u6027\u8102\u80aa\u809d\uff09\u9776\u70b9\u53ca\u673a\u5236\u6c47\u603b\uff08\u4e00\uff09"},"content":{"rendered":"<p>\u4f5c\u8005\uff1a\u5929\u7136\u7522\u7269\u9776\u9ede\u767c\u73fe<\/p>\n<p>1.Nat Metab | \u7ede\u80a1\u84dd\u4e2d\u5c0f\u5206\u5b50XLIX\u9776\u5411WDR6\u6291\u5236\u809d\u810f\u8102\u8d28\u5408\u6210\u6cbb\u7597\u975e\u9152\u7cbe\u6027\u8102\u80aa\u809d<\/p>\n<p>2023\u5e749\u670821\u65e5\uff0c\u5c71\u4e1c\u7b2c\u4e00\u533b\u79d1\u5927\u5b66\u9644\u5c5e\u7701\u7acb\u533b\u9662\u8d75\u5bb6\u519b\u3001\u8584\u6d9b\u3001\u9ad8\u8046\u5171\u540c\u901a\u8baf\u5728Nature Metabolism\u53d1\u8868\u4e86\u9898\u4e3a\u201cUpregulation of WDR6 Drives Hepatic de novo Lipogenesis in Insulin Resistance in Mice\u201d\u7684\u7814\u7a76\u8bba\u6587\u3002\u53d1\u73b0WD\u91cd\u590d\u57df6\uff08WD repeats domain 6\uff0cWDR6\uff09\u4fc3\u8fdb\u80f0\u5c9b\u7d20\u62b5\u6297\u671f\u95f4\u809d\u810fDNL\u3002\u5e76\u4ece\u4e2d\u836f\u7ede\u80a1\u84dd\u4e2d\u7b5b\u9009\u548c\u8f6c\u5316\u4e86\u4e00\u4e2a\u5929\u7136\u5c0f\u5206\u5b50\u5316\u5408\u7269\u2014XLIX\u3002\u8be5\u5316\u5408\u7269\u53ef\u9776\u5411WDR6\uff0c\u6291\u5236\u5176\u4ecb\u5bfc\u7684\u809d\u810f\u8102\u8d28\u5408\u6210\uff0c\u4e3a\u9884\u9632\u548c\u6cbb\u7597NAFLD\u63d0\u4f9b\u4e86\u65b0\u7684\u6f5c\u5728\u6cbb\u7597\u9776\u70b9\u548c\u7b56\u7565\u3002<\/p>\n<p>\u95b1\u8b80\u5168\u6587\uff1a<a href=\"https:\/\/mp.weixin.qq.com\/s\/JmjmArRvl7QSOy6LuaNzUw\">https:\/\/mp.weixin.qq.com\/s\/JmjmArRvl7QSOy6LuaNzUw<\/a><\/p>","protected":false},"excerpt":{"rendered":"<p>\u4f5c\u8005\uff1a\u5929\u7136\u7522\u7269\u9776\u9ede\u767c\u73fe 1.Nat Metab | \u7ede\u80a1\u84dd\u4e2d\u5c0f\u5206\u5b50XLIX\u9776\u5411WDR6\u6291\u5236\u809d\u810f\u8102\u8d28\u5408\u6210\u6cbb\u7597\u975e\u9152\u7cbe\u6027\u8102\u80aa\u809d 2023\u5e749\u670821\u65e5\uff0c\u5c71\u4e1c\u7b2c\u4e00\u533b\u79d1\u5927\u5b66\u9644\u5c5e\u7701\u7acb\u533b\u9662\u8d75\u5bb6\u519b\u3001\u8584\u6d9b\u3001\u9ad8\u8046\u5171\u540c\u901a\u8baf\u5728Nature Metabolism\u53d1\u8868\u4e86\u9898\u4e3a\u201cUpregulation of WDR6 Drives Hepatic de novo Lipogenesis in Insulin Resistance in Mice\u201d\u7684\u7814\u7a76\u8bba\u6587\u3002\u53d1\u73b0WD\u91cd\u590d\u57df6\uff08WD repeats domain 6\uff0cWDR6\uff09\u4fc3\u8fdb\u80f0\u5c9b\u7d20\u62b5\u6297\u671f\u95f4\u809d\u810fDNL\u3002\u5e76\u4ece\u4e2d\u836f\u7ede\u80a1\u84dd\u4e2d\u7b5b\u9009\u548c\u8f6c\u5316\u4e86\u4e00\u4e2a\u5929\u7136\u5c0f\u5206\u5b50\u5316\u5408\u7269\u2014XLIX\u3002\u8be5\u5316\u5408\u7269\u53ef\u9776\u5411WDR6\uff0c\u6291\u5236\u5176\u4ecb\u5bfc\u7684\u809d\u810f\u8102\u8d28\u5408\u6210\uff0c\u4e3a\u9884\u9632\u548c\u6cbb\u7597NAFLD\u63d0\u4f9b\u4e86\u65b0\u7684\u6f5c\u5728\u6cbb\u7597\u9776\u70b9\u548c\u7b56\u7565\u3002 \u95b1\u8b80\u5168\u6587\uff1ahttps:\/\/mp.weixin.qq.com\/s\/JmjmArRvl7QSOy6LuaNzUw<\/p>\n","protected":false},"author":1,"featured_media":15352,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[16,11,1,33],"tags":[],"class_list":["post-15351","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-health-environment","category-others","category-public-health","category-western-medicine"],"_links":{"self":[{"href":"https:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/posts\/15351","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/comments?post=15351"}],"version-history":[{"count":1,"href":"https:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/posts\/15351\/revisions"}],"predecessor-version":[{"id":15353,"href":"https:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/posts\/15351\/revisions\/15353"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/media\/15352"}],"wp:attachment":[{"href":"https:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/media?parent=15351"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/categories?post=15351"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/tags?post=15351"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}