{"id":5311,"date":"2021-12-18T20:29:10","date_gmt":"2021-12-18T20:29:10","guid":{"rendered":"http:\/\/www.drknowhk.org\/?p=5311"},"modified":"2024-03-13T08:20:15","modified_gmt":"2024-03-13T08:20:15","slug":"%e4%b8%ad%e6%96%87-epigallocatechin-3-gallate-an-active-ingredient-of-traditional-chinesemedicines-inhibits-the-3clpro-activity-of-sars-cov-2","status":"publish","type":"post","link":"https:\/\/www.drknowhk.org\/mo\/%e4%b8%ad%e6%96%87-epigallocatechin-3-gallate-an-active-ingredient-of-traditional-chinesemedicines-inhibits-the-3clpro-activity-of-sars-cov-2\/","title":{"rendered":"Epigallocatechin-3-gallate, an active ingredient of Traditional ChineseMedicines, inhibits the 3CLpro activity of SARS-CoV- 2"},"content":{"rendered":"<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-8432\" src=\"http:\/\/www.drknowhk.org\/wp-content\/uploads\/2024\/03\/E8F2B5A9-1A11-425E-8A3C-3FD6D2071823.jpeg\" alt=\"\" width=\"222\" height=\"172\" \/><br \/>\n\u985e\u578b: \u9023\u7d50<br \/>\n\u4f5c\u8005: Ashuai Du, Rong Zheng, Cyrollah Disoma, Shiqin Li, Zongpeng Chen, Sijia Li, Pinjia Liu, Yuzheng Zhou, Yilun Shen, Sixu Liu, Yongxing Zhang, Zijun Dong, QinglongYang, Moyed Alsaadawe, Aroona Razzaq, Yuyang Peng, Xuan Chen, Liqiang Hu, Jian Peng, Qianjun Zhang, Taijiao Jiang, Long Mo, Shanni Li, Zanxian Xia<br \/>\n\u51fa\u8655: Elsevier<br \/>\n\u9023\u7d50: <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0141813021002804?via%3Dihub\">https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0141813021002804?via%3Dihub<\/a><br \/>\n<\/p>","protected":false},"excerpt":{"rendered":"<p>The main protease of SARS-CoV-2, 3CLpro, is an attractive target for antiviral inhibitors due to its indispensable role in viral replication and gene expression of viral proteins. The search of compounds that can effectively inhibit the crucial activity of 3CLpro, which results to interference of the virus life cycle, is now widely pursued. Here, we report that epigallocatechin-3-gallate (EGCG), an active ingredient of Chinese herbal medicine (CHM), is a potent inhibitor of 3CLpro with half-maximum inhibitory concentration (IC50) of 0.874 \u00b1 0.005 \u03bcM\u2026<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[45],"tags":[],"class_list":["post-5311","post","type-post","status-publish","format-standard","hentry","category-chinese-and-western-therapeutic-pharmacological-research"],"_links":{"self":[{"href":"https:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/posts\/5311","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/comments?post=5311"}],"version-history":[{"count":1,"href":"https:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/posts\/5311\/revisions"}],"predecessor-version":[{"id":5312,"href":"https:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/posts\/5311\/revisions\/5312"}],"wp:attachment":[{"href":"https:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/media?parent=5311"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/categories?post=5311"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.drknowhk.org\/mo\/wp-json\/wp\/v2\/tags?post=5311"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}